Trial reportBMC medical research methodology2020
Application of the matched nested case-control design to the secondary analysis of trial data.
Trial report in BMC medical research methodology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Trial
- Time to first recurrent thrombosis in adults with thrombotic antiphospholipid syndrome: a registry-based retrospective cohort study.Clinical rheumatology · 2026Article
- Clinical hepatic indices serve as predictive markers for sinusoidal obstruction syndrome after allogeneic HSCT.International journal of hematology · 2026Article
- Cognitive Decline Preceding Incident Cardiovascular Events in Older Adults.JAMA network open · 2026Article
- Incidence and risk factors for hospital-attributable central line-associated bloodstream infections in adult inpatients in a tertiary hospital.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Menopausal hormone therapy and the risk of systemic lupus erythematosus and systemic sclerosis: a population-based nested case-control study.Rheumatology (Oxford, England) · 2025Article
- Effects of Pancreatitis and Type 2 Diabetes Mellitus on the Development of Pancreatic Cancer: A Nationwide Nested Case-Control Study.Diabetes & metabolism journal · 2025Article
- Genome-Wide Interaction Study of Dietary Intake and Colorectal Cancer Risk in the UK Biobank.JAMA network open · 2024Article
- Risk Prediction of Metachronous Colorectal Cancer from Molecular Features of Adenomas: A Nested Case-Control Study.Cancer research communications · 2023Article
- Initiation Patterns and Transitions Among Adults Using Stimulant Drugs: Latent Transition Analysis.Journal of medical Internet research · 2023Article
- High Dietary Phosphorus Is Associated with Increased Breast Cancer Risk in a U.S. Cohort of Middle-Aged Women.Nutrients · 2023Article
- Determinants of postpartum uterine atony in urban South Ethiopia: a community-based unmatched nested case-control study.BMC pregnancy and childbirth · 2023Article
- Lifestyle-related habits and factors before and after cardiovascular diagnosis: a case control study among 2,548 Swedish individuals.The international journal of behavioral nutrition and physical activity · 2023Article
- Associations Between Natural Language Processing-Enriched Social Determinants of Health and Suicide Death Among US Veterans.JAMA network open · 2023Article
- Developing and testing a Corona VaccinE tRiAL pLatform (COVERALL) to study Covid-19 vaccine response in immunocompromised patients.BMC infectious diseases · 2022Article
- Article
- Association Between DPP-4 Inhibitors and Events of Colorectal and Liver Cancers in Patients With Diabetes Receiving Second-Line Agents: A Nested Case-Control Study.Frontiers in oncology · 2022Article
- Evaluation of a web-based intervention to optimize perinatal emotional wellbeing: A nested case-control study.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundA nested case-control study is an efficient design that can be embedded within an existing cohort study or randomised trial. It has a number of advantages compared to the conventional case-control design, and has the potential to answer important research questions using untapped prospectively collected data.
methodsWe demonstrate the utility of the matched nested case-control design by applying it to a secondary analysis of the Abnormal Doppler Enteral Prescription Trial. We investigated the role of milk feed type and changes in milk feed type in the development of necrotising enterocolitis in a group of 398 high risk growth-restricted preterm infants.
resultsUsing matching, we were able to generate a comparable sample of controls selected from the same population as the cases. In contrast to the standard case-control design, exposure status was ascertained prior to the outcome event occurring and the comparison between the cases and matched controls could be made at the point at which the event occurred. This enabled us to reliably investigate the temporal relationship between feed type and necrotising enterocolitis.
conclusionsA matched nested case-control study can be used to identify credible associations in a secondary analysis of clinical trial data where the exposure of interest was not randomised, and has several advantages over a standard case-control design. This method offers the potential to make reliable inferences in scenarios where it would be unethical or impractical to perform a randomised clinical trial.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.