SynthesisCurrent pharmaceutical design2020
Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis.
Synthesis in Current pharmaceutical design, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Daily use of chlorine dioxide effectively treats halitosis: A meta-analysis of randomised controlled trials.PloS one · 2023Pooled it
- Comparative evaluation of the antimicrobial activity of three tea extracts against chlorhexidine, chlorine dioxide, and cariogenic bacteria: AnJournal of conservative dentistry and endodontics · 2026Article
- Effect of Antimicrobial Filler on Ethylene-Vinyl Acetate (EVA) Composites Property.Materials (Basel, Switzerland) · 2025Article
- Review
- Antimicrobial properties and toxicity challenges of chlorine dioxide used in alternative medicine.Scientific reports · 2025Article
- Comparing In Vitro Virucidal Efficacy of Commercially Available Mouthwashes Against Native High-Risk Human Papillomavirus Types 16 and 18.Microorganisms · 2025Article
- Identifying the Multifactorial Triggers of Monthly Recurrent HSV-1 Reactivation: A Case Report.International medical case reports journal · 2025Article
- Review
- Multidisciplinary Management of Oral Manifestations in Pregnant Women with Beta-Thalassemia Major: A Case Report.International medical case reports journal · 2024Article
- Short- and long term antibacterial effects of a single rinse with different mouthwashes: A randomized clinical trial.Heliyon · 2023Article
- Article
- Holistic Approach of a Leukemic Child Suffering from Oral Mucositis with Coinfections: A Case Report.International medical case reports journal · 2023Article
- Inactivation methods for human coronavirus 229E on various food-contact surfaces and foods.Food control · 2022Article
- Use of Ivermectin and Chlorine Dioxide for COVID-19 Treatment and Prophylaxis in Peru: A Narrative Review.Cureus · 2022Review
- Evidence on the Use of Mouthwash for the Control of Supragingival Biofilm and Its Potential Adverse Effects.Antibiotics (Basel, Switzerland) · 2022Review
- Orally Administered Probiotics DecreaseFrontiers in pharmacology · 2021Review
- Review
- Acute oral toxicity and mucosal irritation of a mouthwash containing chlorhexidine and chlorine dioxide in animal models.Journal of oral biology and craniofacial researchArticle
- A comparative evaluation of the antimicrobial efficacy of Chlorhexidine and Chlorine dioxide on self-ligating brackets contaminated with Streptococcus mutans biofilm- An In vitro study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEffective and selective oral rinses are required in the daily medical and dental practice. Currently mouthwashes used have substantial side effects.
objectivesOur aim was to evaluate the efficacy of chlorine dioxide-containing mouthwashes in comparison with other previously established mouth rinses in healthy adults using oral hygiene indices.
methodsThis work was registered in PROSPERO (CRD42018099059) and carried out using multiple databases and reported according to the PRISMA statement. The search terms used were "chlorine dioxide" AND "oral", and only randomised controlled trials (RCTs) were included. The primary outcome was the alteration of the plaque index (PI), while the secondary outcomes were the gingival index (GI) and bacterial counts. For the risk of bias assessment, the Cochrane Risk of Bias Tool was used. Statistical analysis for data heterogeneity was performed by Q-value and I2-tests.
results364 articles were found in the databases. After the selection process, only five RCTs were eligible for meta-analysis. Data heterogeneity was low. There were no statistical differences in effectiveness between chlorine dioxide and other effective mouth rinses in PI (0.720±0.119 vs 0.745±0.131; 95%; confidence intervals (CIs): 0.487-0.952 vs 0.489-1.001, respectively) and GI (0.712±0.130 vs 0.745±0.131; 95% CIs: 0.457-0.967 vs 0.489- 1.001, respectively) and also in bacterial counts.
conclusionChlorine dioxide reduces both plaque and gingival indices and bacterial counts in the oral cavity similar to other routinely used oral rinses, however, the evidence supporting this outcome is very limited. Therefore, further large scale RCTs are needed to decrease the risk of bias.
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