Evidence map›Paper›PMID 32410160›Full record

ArticleUpdates in surgery2021

Developing a tool that could reliably refute total thyroidectomy for solitary Bethesda IV thyroid nodules.

Sohail Bakkar, Elisabetta Macerola, Agnese Proietti, Qusai Aljarrah, Khaled Al-Omar, Gabriele Materazzi, Fulvio Basolo, Paolo Miccoli

Abstract read
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Article in Updates in surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sohail BakkarDepartment of Surgery, Faculty of Medicine, The Hashemite University, Zarqa, 13133, Jordan. sohail.bakkar@gmail.com.ORCID http://orcid.org/0000-0001-8479-5901
Elisabetta MacerolaDepartment of Surgical, Medical, Pathology, and Critical Care, The University of Pisa, 56124, Pisa, Italy.
Agnese ProiettiDepartment of Surgical, Medical, Pathology, and Critical Care, The University of Pisa, 56124, Pisa, Italy.
Qusai AljarrahDepartment of Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Khaled Al-OmarDepartment of Surgery, Faculty of Medicine, The Hashemite University, Zarqa, 13133, Jordan.
Gabriele MaterazziDepartment of Surgical, Medical, Pathology, and Critical Care, The University of Pisa, 56124, Pisa, Italy.
Fulvio BasoloDepartment of Surgical, Medical, Pathology, and Critical Care, The University of Pisa, 56124, Pisa, Italy.
Paolo MiccoliDepartment of Surgical, Medical, Pathology, and Critical Care, The University of Pisa, 56124, Pisa, Italy.
University of Pisa · ITHashemite University · JOJordan University of Science and Technology · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the reliability of a simple, accessible, cost-effective rule-out tool, for use in triaging patients with Bethesda IV nodules to appropriate surgery.

methodsThe diagnostic tool was assembled by combining the negativity for suspicious ultrasound features (irregular margins, microcalcification, and a taller-than-wide orientation), and mutational marker negativity (BRAF and NRAS). The tool, (US

results10 out of 167 lesions were positive for a mutational marker. These underwent TT, and only 2/10 (20%) were benign, on final histology. In 6/8 malignant lesions, TT was concordant with current clinical guidelines. 157 patients comprised the negative study cohort, for both mutational markers and suspicious US features. These underwent thyroid lobectomy, and 17 cases resulted in malignancy, only 8 of which required completion thyroidectomy. Accordingly, the NPV of (US

conclusionUS

Indexed as

Diagnostic Techniques, EndocrineThyroidectomyAdolescentAdultAgedCost-Benefit AnalysisFemaleGenetic MarkersGTP PhosphohydrolasesHumansMaleMembrane ProteinsMiddle AgedMutationPredictive Value of TestsProto-Oncogene Proteins B-rafBRAF protein, humanGenetic MarkersGTP PhosphohydrolasesMembrane ProteinsNRAS protein, humanProto-Oncogene Proteins B-rafBethesda IVExtent of thyroid surgeryIndeterminate thyroid noduleThyroid cancer

Identifiers

PMID32410160
OpenAlexW3026086656

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.