SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2020
Health-related quality of life scores of typically developing children and adolescents around the world: a meta-analysis with meta-regression.
Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Non-disease specific patient-reported outcome measures of health-related quality of life in juvenile idiopathic arthritis: a systematic review of current research and practice.Rheumatology international · 2022Pooled it
- Asthma and sleep disordered breathing in the pediatric adenotonsillectomy trial for snoring study.Sleep & breathing = Schlaf & Atmung · 2024Trial
- Longitudinal Improvements in Health-Related Quality of Life Among Children Enrolled in the CANadian Paediatric Weight Management Registry (CANPWR) Over 3 Years.Pediatric obesity · 2026Article
- Pilot study to investigate sleep and breathing related complications in children and young people with osteogenesis imperfecta.BMC musculoskeletal disorders · 2025Observational
- Caregivers of children with Down Syndrome adapt their child's diet and experience barriers and impacts on quality of life.International journal of pediatric otorhinolaryngology · 2025Observational
- Predicting children and adolescents at high risk of poor health‑related quality of life using machine learning methods.Health and quality of life outcomes · 2025Article
- Impact of Testosterone on Endothelial Function Varies by GnRH Agonist Treatment.Journal of the Endocrine Society · 2025Article
- What Shapes Quality of Life in Youth? A Multidimensional Approach from Lifestyle to Residential Context-Cor-School Study.Healthcare (Basel, Switzerland) · 2025Article
- Health-Related Quality of Life in Juvenile Idiopathic Arthritis: A Systematic Review of Phase III Clinical Trials.Journal of clinical medicine · 2025Review
- Effects of different levels of physical activity on the health-related quality of life among rural junior high school students in China: the moderating role of parental co-participation in physical activities.Frontiers in public health · 2025Article
- Measuring health-related quality of life in children with suspected genetic conditions: validation of the PedsQL proxy-report versions.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Brazilian children's quality of life during the COVID-19 pandemic: analysis of contextual factors and dimensions.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2024Observational
- Association between healthy lifestyle factors and health-related quality of life among Chinese adolescents: the moderating role of gender.Health and quality of life outcomes · 2023Article
- Association of Socioeconomic Factors and Physical Activity with Health-Related Quality of Life in Italian Middle School Children: An Exploratory Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2023Article
- Spanish validation of the Pediatric Quality of Life Inventory (PedsQL™ 4.0) for parent report for toddlers (ages 2-4).Health and quality of life outcomes · 2023Article
- Article
- PedsQL™ Spinal Cord Injury Module: Reliability and Validity.Topics in spinal cord injury rehabilitation · 2022Article
- Sex differences in children's health status as measured by the Pediatric Quality of Life Inventory (PedsQL)™: cross-sectional findings from a large school-based sample in the Netherlands.BMC pediatrics · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeIn the context of identifying consequences and evaluating interventions for rare diseases, health-related quality of life (HRQL) measures are often used. Conclusions about HRQL are difficult to make as the participants are likely drawn from different countries. A global estimate of HRQL with estimates of variation would permit pooling of data from diverse sources. The aim was to estimate a global HRQL score of typically developing children and adolescents on the Pediatric Quality of Life Inventory (PedsQL™) and to identify sources of variation across studies.
methodsA systematic search was conducted in December 2018 on four databases: MEDLINE, EMBASE, CINAHL and PsycINFO. Inclusion criteria were all population health studies or validation studies using the self-report version of the PedsQL™ for typically developing children aged 5 to 18 years. Quality appraisal was conducted using the Appraisal Tool for Cross-Sectional Studies. Meta-analysis and meta-regression were conducted.
resultsA total of 66 studies with a sample size of 67,805 participants were included in this analysis. The average QOL score across all studies was 80.9 (CI 78.6-83.2). Univariate analyses showed that region, minimum age of sample and income of country, was associated with the total HRQL score. Subgroup analysis showed that there was an effect of age and region on HRQL scores.
conclusionResults of this review provide ranges of pediatric HRQL across personal factors and regions that can be used for normative comparisons of HRQL. Interpretation of scores on generic measures should always take into consideration the contextual influences in the child's life. REGISTRATION: PROSPERO, CRD42019128313 https://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42019128313 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.