ArticleJournal of autism and developmental disorders2021
Trajectories of Autism Symptom Severity Change During Early Childhood.
Article in Journal of autism and developmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Predicting early intervention outcomes in autism via individual participant data mega-analysis.Molecular autism · 2026Pooled it
- Overall prognosis of preschool autism spectrum disorder diagnoses.The Cochrane database of systematic reviews · 2022Pooled it
- A Systematic Review of Passing as Non-autistic in Autism Spectrum Disorder.Clinical child and family psychology review · 2021Pooled it
- Continuity in social communication development among school-aged siblings of autistic children.Developmental psychology · 2026Article
- Mitigating Sex-Related Biases to Elucidate the Autism Phenotype.Biological psychiatry · 2026Review
- Studying Development of Psychopathology Using Changing Measures to Account for Heterotypic Continuity.JAACAP open · 2026Article
- Evaluating physician knowledge of autism spectrum disorder: addressing diagnostic challenges, comorbidities, and the need for targeted education.Archives of medical science : AMS · 2026Article
- Clinical and Research Insights from Pre-Emptive Early Intervention for Neurodevelopmental Disorders: A Case Series.Children (Basel, Switzerland) · 2025Article
- Current situation and influencing factors of Chinese children's diagnosis delay in autism.Journal of neurodevelopmental disorders · 2025Article
- Sex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium.JAMA network open · 2025Article
- Trajectories of autism symptom severity for boys and girls across childhood.Autism : the international journal of research and practice · 2025Article
- Early neurophysiological markers of aberrant auditory processing associated with increased risk of autism spectrum disorder: A systematic review.Pediatric investigation · 2025Review
- Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study.Autism research : official journal of the International Society for Autism Research · 2025Article
- Latent trajectories of mental health service use in an Australian state population cohort of children.The Australian and New Zealand journal of psychiatry · 2025Article
- Impact of imitation abilities on social communication in autistic children: evidence from an Early Start Denver Model intervention study.Molecular autism · 2025Article
- Age-Related Trajectories of Autistic Traits in Children With Angelman Syndrome.Autism research : official journal of the International Society for Autism Research · 2025Article
- Reliably quantifying the severity of social symptoms in children with autism using ASDSpeech.Translational psychiatry · 2025Article
- Psychometric properties of the Revised Illness Perception Questionnaire among Iranian parents of children with autism spectrum disorder.International journal of developmental disabilities · 2025Article
- Investigating the ADOS-2 calibrated severity score: insights from the ELENA cohort.Frontiers in child and adolescent psychiatry · 2025Article
- An Overview of Pharmacotherapy in the Management of Children with Autism Spectrum Disorder at a Public Hospital in KwaZulu-Natal.Child psychiatry and human development · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Autism symptom severity change was evaluated during early childhood in 125 children diagnosed with autism spectrum disorder (ASD). Children were assessed at approximately 3 and 6 years of age for autism symptom severity, IQ and adaptive functioning. Each child was assigned a change score, representing the difference between ADOS Calibrated Severity Scores (CSS) at the two ages. A Decreased Severity Group (28.8%) decreased by 2 or more points; a Stable Severity Group (54.4%) changed by 1 point or less; and an Increased Severity Group (16.8%) increased by 2 or more points. Girls tended to decrease in severity more than boys and increase in severity less than boys. There was no clear relationship between intervention history and membership in the groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.