Evidence map›Paper›PMID 32409933›Full record

ArticleArchives of toxicology2020

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE

Marie K Reumann, Jenny Schaefer, Bjoern Titz, Romina H Aspera-Werz, Ee Tsin Wong, Justyna Szostak, Victor Häussling, Sabrina Ehnert, Patrice Leroy, Wei Teck Tan and 11 more

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  11. The impact of E-cigarette vaping and vapour constituents on bone health.Journal of inflammation (London, England) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 5 countries.

Marie K ReumannSiegfried Weller Research Institute, BG Unfallklinik, Eberhard Karls University Tuebingen, Schnarrenbergstr. 95, 72076, Tuebingen, Germany.
Jenny SchaeferSiegfried Weller Research Institute, BG Unfallklinik, Eberhard Karls University Tuebingen, Schnarrenbergstr. 95, 72076, Tuebingen, Germany.
Bjoern TitzPMI R&D, Phillip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchatel, Switzerland.
Romina H Aspera-WerzSiegfried Weller Research Institute, BG Unfallklinik, Eberhard Karls University Tuebingen, Schnarrenbergstr. 95, 72076, Tuebingen, Germany.
Ee Tsin WongPMI R&D, Phillip Morris International Research Laboratories Pte. Ltd, Science Park II, Singapore.
Justyna SzostakPMI R&D, Phillip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchatel, Switzerland.
Victor HäusslingSiegfried Weller Research Institute, BG Unfallklinik, Eberhard Karls University Tuebingen, Schnarrenbergstr. 95, 72076, Tuebingen, Germany.
Sabrina EhnertSiegfried Weller Research Institute, BG Unfallklinik, Eberhard Karls University Tuebingen, Schnarrenbergstr. 95, 72076, Tuebingen, Germany.
Patrice LeroyPMI R&D, Phillip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchatel, Switzerland.
Wei Teck TanPMI R&D, Phillip Morris International Research Laboratories Pte. Ltd, Science Park II, Singapore.
Arkadiusz KuczajPMI R&D, Phillip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchatel, Switzerland.
Christof AudretschDepartment of Trauma and Reconstructive Surgery, BG Unfallklinik, Eberhard Karls University, Tuebingen, Germany.
Fabian SpringerDepartment of Radiology, BG Unfallklinik Tuebingen and University Hospital Tuebingen, Tuebingen, Germany.
Andreas BadkeDepartment of Trauma and Reconstructive Surgery, BG Unfallklinik, Eberhard Karls University, Tuebingen, Germany.
Peter AugatInstitute for Biomechanics, BG Unfallklinik Murnau, Germany & Paracelsus Medical University, Salzburg, Austria.
Leticia Quentanilla-FendDepartment of Pathology, Eberhard Karls University, Tuebingen, Germany.
Manuela MartellaDepartment of Pathology, Eberhard Karls University, Tuebingen, Germany.
K Monica LeeAltria Client Services LLC, 6601 West Broad Street, Richmond, VA, USA.
Manuel C PeitschPMI R&D, Phillip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchatel, Switzerland.
Julia HoengPMI R&D, Phillip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchatel, Switzerland.
Andreas K NusslerSiegfried Weller Research Institute, BG Unfallklinik, Eberhard Karls University Tuebingen, Schnarrenbergstr. 95, 72076, Tuebingen, Germany. andreas.nuessler@med.uni-tuebingen.de.ORCID http://orcid.org/0000-0002-6666-6791
BG Klinik Tübingen · DEPhilip Morris International (Switzerland) · CHParacelsus Medical University · ATSingapore Science Park · SGUniversity of Tübingen · DEAltria (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cigarette smoke (CS) exposure is one of the leading risk factors for human health. Nicotine-containing inhalable products, such as e-cigarettes, can effectively support tobacco harm reduction approaches. However, there are limited comparative data on the effects of the aerosols generated from electronic vapor products (e-vapor) and CS on bone. Here, we report the effects of e-vapor aerosols and CS on bone morphology, structure, and strength in a 6-month inhalation study. Eight-week-old ApoE

Indexed as

Electronic Nicotine Delivery SystemsAnimalsBone and BonesCigarette SmokingE-Cigarette VaporFemaleInhalation ExposureMice, Knockout, ApoESmokeTime FactorsVapingX-Ray MicrotomographyE-Cigarette VaporSmokeApoE–/– mouse modelBone biomechanical propertiesBone structureCigarette smokingE-vapor aerosol

Identifiers

PMID32409933
PMCPMC7303066
OpenAlexW3025791741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.