Evidence map›Paper›PMID 32409886›Full record

ArticleVirchows Archiv : an international journal of pathology2020

Rare MDM2 amplification in a fat-predominant angiomyolipoma.

Maria Del Carmen Rodriguez Pena, Jennifer Gordetsky, Patricia T Greipp, Shi Wei, Guido Martignoni, George J Netto, Shuko Harada, Carlos N Prieto Granada

Abstract read
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Article in Virchows Archiv : an international journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Maria Del Carmen Rodriguez PenaPathology Department, University of Alabama at Birmingham, Birmingham, AL, USA. marie.mcrp@gmail.com.
Jennifer GordetskyPathology Department, Vanderbilt University Medical Center, Nashville, TN, USA.
Patricia T GreippPathology Department, Mayo Clinic, Rochester, MN, USA.
Shi WeiPathology Department, University of Alabama at Birmingham, Birmingham, AL, USA.
Guido MartignoniDepartment of Diagnostic and Public Health, University of Verona, Verona, Italy.
George J NettoPathology Department, University of Alabama at Birmingham, Birmingham, AL, USA.
Shuko HaradaPathology Department, University of Alabama at Birmingham, Birmingham, AL, USA.
Carlos N Prieto GranadaPathology Department, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USCasa di Cura Villa Garda · ITMayo Clinic in Arizona · USVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiomyolipomas (AMLs) are triphasic tumors (smooth muscle, vascular and adipocytic components) with myomelanocytic differentiation, arising most commonly in the kidneys, which can show predominant epithelioid morphology and fat-predominant or fat-poor variants. Fat-predominant AMLs can show areas of hypercellularity and lipoblast-like cells, and these features can mimic well-differentiated liposarcoma (WDLS). To date, only one documented metastatic epithelioid AML showed unequivocal MDM2 amplification by fluorescence in situ hybridization. We describe our findings in a series of 35 AMLs including epithelioid, fat-poor, and fat-predominant variants, following interrogation of the MDM2 locus by FISH and CISH assays. MDM2 amplification was detected in 1 fat-predominant AML. Our findings demonstrate that rare MDM2 amplifications can occur in AMLs. We favor that this finding likely represents a "molecular bystander" event since these tumors are mainly driven by aberrations in the TSC1/TSC2 genes. Nevertheless, the presence of MDM2 amplification in a fat-predominant AML could present a potential diagnostic pitfall, particularly when confronted with the differential diagnosis of fat-predominant AML and WDLS in limited material from the retroperitoneum.

Indexed as

Gene AmplificationAdipose TissueAdultAgedAged, 80 and overAngiomyolipomaBiomarkers, TumorDiagnosis, DifferentialFemaleGenetic Predisposition to DiseaseHumansIn Situ Hybridization, FluorescenceKidney NeoplasmsMaleMiddle AgedPhenotypeBiomarkers, TumorMDM2 protein, humanProto-Oncogene Proteins c-mdm2Chromogenic in situ hybridizationFluorescent in situ hybridizationMDM2 amplificationRenal angiomyolipomaWell-differentiated liposarcoma

Identifiers

PMID32409886
OpenAlexW3024948665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.