Evidence map›Paper›PMID 32409849›Full record

ArticleJournal of molecular histology2020

Comprehensive profiling of circRNAs and the tumor suppressor function of circHIPK3 in clear cell renal carcinoma.

Haomin Li, Baoli Heng, Peng Ouyang, Xuexia Xie, Tingshun Zhang, Guo Chen, Zheng Chen, Kahong Cheang, Caiyong Lai

Abstract read
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In one paragraph

Article in Journal of molecular histology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  15. Role of Circular RNA in Kidney-Related Diseases.Frontiers in pharmacology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Haomin LiDepartment of Urology, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Road, Guangzhou, China.
Baoli HengYingde Center, Institute of Kidney Surgery, Jinan University, Guangdong, China. bolyheng@126.com.ORCID http://orcid.org/0000-0003-3648-0053
Peng OuyangDepartment of Urology, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Road, Guangzhou, China.
Xuexia XieDepartment of Urology, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Road, Guangzhou, China.
Tingshun ZhangDepartment of Urology, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Road, Guangzhou, China.
Guo ChenDepartment of Urology, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Road, Guangzhou, China.
Zheng ChenDepartment of Urology, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Road, Guangzhou, China.
Kahong CheangCentor Medico Kong, Wa-Estrada do Arco NO. S124, Ki Kuan Bairro, AZ, Macau.
Caiyong LaiDepartment of Urology, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Road, Guangzhou, China. lcy2015@jnu.edu.cn.
First Affiliated Hospital of Jinan University · CNJinan University · CNPeople's Hospital of Yangzhong · CN

Funding

Fundamental Research Funds for the Central Universities 11618303Fundamental Research Funds for the Central Universities 21618306Leading Specialist Construction Project-Department of Urology, the First Affiliated Hospital, Jinan University 711006Medical Scientific Research Foundation of Guangdong Province A2019571Science and Technology Planning Project of Yangjiang (CN) 33518008the National Key R&D Program of China 2016 YFC 1305700
6 · The paper itself

Abstract

Increasing evidence has indicated that circular RNAs (circRNAs) play a key role in the development and progression of diverse cancers, but their role in clear cell renal carcinoma (CCRCC) tumorigenesis is not well understood. In this study, we firstly performed comprehensive circRNA-seq from CCRCC tissues and pair-matched adjacent normal tissues. In total, 1184 circRNAs were dysregulated in human CCRCC tissues compared with those in adjacent normal tissues. We randomly selected four circRNAs, including circHIPK3 (circBase ID: hsa_circ_0000284), to test the circRNA-seq data in another 40 CCRCC tissues by quantitative real-time PCR (qRT-PCR). Furthermore, we found that circHIPK3 was downregulated in CCRCC tissues and cell lines. Overexpression of circHIPK3 effectively suppressed CCRCC cell invasion and migration in vitro, and inhibited CCRCC cell proliferation in vitro and in vivo. Moreover, bioinformatic analysis and luciferase reporter assay showed that circHIPK3 targeted miR-637 in CCRCC cells. Hence, CircHIPK3 may represent a tumor suppressor and target miR-637 in clear cell renal carcinoma.

Indexed as

AnimalsCarcinoma, Renal CellCell Line, TumorCell MovementCell ProliferationDown-RegulationGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsKidneyKidney NeoplasmsMice, NudeMicroRNAsProtein Serine-Threonine KinasesRNA, CircularUp-RegulationHIPK3 protein, humanIntracellular Signaling Peptides and ProteinsMicroRNAsMIRN637 microRNA, humanProtein Serine-Threonine KinasesRNA, CircularCircHIPK3CircRNACircular RNAClear cell renal carcinomamiR-637Renal carcinoma

Identifiers

PMID32409849
OpenAlexW3024124160

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.