ArticleMolecular psychiatry2021
Longitudinal brain connectivity changes and clinical evolution in Parkinson's disease.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Virtual reality balance training to improve balance and mobility in Parkinson's disease: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- Eight-year longitudinal changes in functional connectivity of the fatigue network in Parkinson's disease: evidence from four timepoints.Brain imaging and behavior · 2026Article
- Impact frequency and interval modulate brain network outcomes in a rat model of repetitive mild traumatic brain injury.Scientific reports · 2026Article
- Beyond nigrostriatal dopamine transporter loss: whole-brain DAT depletion patterns discriminate PD phenotypes.European journal of nuclear medicine and molecular imaging · 2026Article
- Resting-state fMRI foundation models enable robust and generalizable latent neural target discovery in cognitive aging interventions.bioRxiv : the preprint server for biology · 2026Article
- Multimodal brain network topology and enhanced computer-aided diagnosis in Parkinson's Disease: a systematic review and meta-analysis.NPJ digital medicine · 2026Article
- Neuronal plasticity and its role in Alzheimer's disease and Parkinson's disease.Neural regeneration research · 2026Article
- Differential Effects of Repetitive Transcranial Magnetic Stimulation on Mood and Pain Symptoms in People With Chronic Pain and Major Depressive Disorders-A Review.European journal of pain (London, England) · 2025Review
- Parkinson's Disease: Bridging Gaps, Building Biomarkers, and Reimagining Clinical Translation.Cells · 2025Review
- Longitudinal Multimodal Functional Imaging: An Essential Tool for Visualizing Pathologic Progression in Parkinson's Disease.Journal of movement disorders · 2025Article
- Electrophysiological Alterations in the Progression of Parkinson's Disease and the Therapeutic Effect of Tetrabenazine on Rats With Levodopa-Induced Dyskinesia.CNS neuroscience & therapeutics · 2025Article
- Radiological markers of CSF α-synuclein aggregation in Parkinson's disease patients.NPJ Parkinson's disease · 2025Article
- Using resting-state functional magnetic resonance imaging and contrastive learning to explore changes in the Parkinson's disease brain network and correlations with gait impairment.Quantitative imaging in medicine and surgery · 2025Article
- Alterations in functional and structural connectivity in the 6-OHDA-induced Parkinsonian rat model.Frontiers in neuroscience · 2025Article
- Functional Brain Network Disruptions in Parkinson's Disease: Insights from Information Theory and Machine Learning.Diagnostics (Basel, Switzerland) · 2024Article
- Stepwise Functional Brain Architecture Correlates with Atrophy in Progressive Supranuclear Palsy.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- A divergent pattern in functional connectivity: a transdiagnostic perspective.Neural regeneration research · 2024Article
- Association of synuclein alpha (Quantitative imaging in medicine and surgery · 2024Article
- Disrupted Brain Network Measures in Parkinson's Disease Patients with Severe Hyposmia and Cognitively Normal Ability.Brain sciences · 2024Article
- A longitudinal evaluation of personalized intrinsic network topography and cognitive decline in Parkinson's disease.The European journal of neuroscience · 2024Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Longitudinal connectivity studies might guide our understanding of the underlying neurodegenerative processes. We report the results of a longitudinal study in patients at different stages of Parkinson's disease (PD), who performed motor and non-motor evaluations and serial resting state (RS) functional MRI (fMRI). Cluster analysis was applied to demographic and clinical data of 146 PD patients to define disease subtypes. Brain network functional alterations were assessed at baseline in PD relative to 60 healthy controls and every year for a maximum of 4 years in PD groups. Progression of brain network changes were compared between patient clusters using RS fMRI. The contribution of network changes in predicting clinical deterioration was explored. Two main PD clusters were identified: mild PD (86 patients) and moderate-to-severe PD (60 patients), with the latter group being older and having earlier onset, longer PD duration, more severe motor, non-motor and cognitive deficits. Within the mild patient cluster, two clinical subtypes were further identified: mild motor-predominant (43) and mild-diffuse (43), with the latter being older and having more frequent non-motor symptoms. Longitudinal functional connectivity changes vary across patients in different disease stages with the coexistence of hypo- and hyper-connectivity in all subtypes. RS fMRI changes were associated with motor, cognitive and non-motor evolution in PD patients. Baseline RS fMRI presaged clinical and cognitive evolution. Our network perspective was able to define trajectories of functional architecture changes according to PD stages and prognosis. RS fMRI may be an early biomarker of PD motor and non-motor progression.
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