ArticleScientific reports2020
Finite deformation elastography of articular cartilage and biomaterials based on imaging and topology optimization.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Intervertebral Disc Elastography to Relate Shear Modulus and Relaxometry in Compression and Bending.Bioengineering (Basel, Switzerland) · 2026Article
- MRI-derived articular cartilage strains predict patient-reported outcomes six months post anterior cruciate ligament reconstruction.Scientific reports · 2025Article
- Image-Based Polygonal Lattices for Mechanical Modeling of Biological Materials: 2D Demonstrations.ACS biomaterials science & engineering · 2023Article
- Image-Based Elastography of Heterochromatin and Euchromatin Domains in the Deforming Cell Nucleus.Small (Weinheim an der Bergstrasse, Germany) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Tissues and engineered biomaterials exhibit exquisite local variation in stiffness that defines their function. Conventional elastography quantifies stiffness in soft (e.g. brain, liver) tissue, but robust quantification in stiff (e.g. musculoskeletal) tissues is challenging due to dissipation of high frequency shear waves. We describe new development of finite deformation elastography that utilizes magnetic resonance imaging of low frequency, physiological-level (large magnitude) displacements, coupled to an iterative topology optimization routine to investigate stiffness heterogeneity, including spatial gradients and inclusions. We reconstruct 2D and 3D stiffness distributions in bilayer agarose hydrogels and silicon materials that exhibit heterogeneous displacement/strain responses. We map stiffness in porcine and sheep articular cartilage deep within the bony articular joint space in situ for the first time. Elevated cartilage stiffness localized to the superficial zone is further related to collagen fiber compaction and loss of water content during cyclic loading, as assessed by independent T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.