ArticleScientific reports2020
Effect of a novel synbiotic on Streptococcus mutans.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Modulating Oral Microbiota to Prevent Dental Caries: A Microbial Ecology Approach.Dentistry journal · 2026Review
- Synbiotics: An Emerging Frontier in Infectious Diseases Control.Probiotics and antimicrobial proteins · 2026Review
- Probiotics, Prebiotics, Synbiotics, Postbiotics, and Bioactive Agents in Modulating Harmful Oral Biofilms.Probiotics and antimicrobial proteins · 2026Review
- Does a link exist between oral microbiota and oral squamous cell carcinoma? A review of current insights.Journal of oral microbiology · 2025Review
- Modulation of the Human Microbiome: Probiotics, Prebiotics, and Microbial Transplants.Advances in experimental medicine and biology · 2025Review
- Potential of Synbiotics and Probiotics as Chemopreventive Agent.Probiotics and antimicrobial proteins · 2024Review
- The strategic role of biotics in dental caries prevention: A scoping review.Food science & nutrition · 2024Article
- How probiotics, prebiotics, synbiotics, and postbiotics prevent dental caries: an oral microbiota perspective.NPJ biofilms and microbiomes · 2024Review
- Synbiotics as potent functional food: recent updates on therapeutic potential and mechanistic insight.Journal of food science and technology · 2024Review
- Antimicrobial activity of Limosilactobacillus fermentum strains isolated from the human oral cavity against Streptococcus mutans.Scientific reports · 2023Article
- Postbiotics Derived fromMolecules (Basel, Switzerland) · 2023Article
- Fast-Setting Calcium Silicate-Based Pulp Capping Cements-Integrated Antibacterial, Irritation and Cytocompatibility Assessment.Materials (Basel, Switzerland) · 2023Article
- Article
- Probiotics: Dawn of a New Era in Dental Caries Management.Journal of pharmacy & bioallied sciences · 2022Review
- Collagen Peptide in a Combinatorial Treatment withInternational journal of molecular sciences · 2022Article
- The Future of Synbiotics: Rational Formulation and Design.Frontiers in microbiology · 2022Review
- Enhanced Spontaneous Antibacterial Activity of δ-MnOFrontiers in bioengineering and biotechnology · 2021Article
- Synbiotics in caries prevention: A scoping review.PloS one · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the effect of L-arginine - (i) on the growth of L. rhamnosus GG (LrG) and (ii) combined LrG synbiotic on the growth of cariogenic S. mutans. Viability of LrG was assessed using MTT/XTT assays, confocal imaging with ADS activity measurement. The effect of L-arginine (0.5%/1%/2%) (2×/24 h) with LrG on S. mutans was evaluated by measuring the colony forming units, biofilm biomass, real-time qPCR and confocal imaging. The pH of the spent media was measured immediately and 24 h post-treatment with assessment of lactic acid. The LrG viability was highest with 2% L-arginine (p < 0.001). Confocal imaging showed that 2% L-arginine increased biofilm thickness of LrG. The 2% L-arginine and LrG synbiotic significantly inhibited the growth of S. mutans (p < 0.001) reducing the viable counts (p = 0.002) and biofilm biomass (p < 0.001). The pH of spent media was the highest when treated with 2% L-arginine and LrG synbiotic (p < 0.001) with no difference between post-treatment and 24 h post-treatment (p > 0.05). Conversely, the 2% L-arginine and LrG synbiotic showed the lowest lactic acid production (p < 0.001). This study demonstrated that L-arginine enhanced the growth of LrG. The 2% L-arginine and LrG synbiotic synergistically inhibits the growth of S. mutans with significant potential to develop as an anti-caries regimen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.