Evidence map›Paper›PMID 32409678›Full record

ArticleThe Journal of antibiotics2020

N-Terminal guanidine derivatives of teicoplanin antibiotics strongly active against glycopeptide resistant Enterococcus faecium.

Zsolt Szűcs, Ilona Bereczki, Erzsébet Rőth, Márton Milánkovits, Eszter Ostorházi, Gyula Batta, Lajos Nagy, Zsuzsanna Dombrádi, Anikó Borbás, Pál Herczegh

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Article in The Journal of antibiotics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zsolt SzűcsDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary.
Ilona BereczkiDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary.
Erzsébet RőthDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary.
Márton MilánkovitsDepartment of Medical Microbiology, Semmelweis University, Budapest, Nagyvárad tér 4, H-1089, Hungary.
Eszter OstorháziDepartment of Medical Microbiology, Semmelweis University, Budapest, Nagyvárad tér 4, H-1089, Hungary.
Gyula BattaDepartment of Organic Chemistry, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary.
Lajos NagyDepartment of Applied Chemistry, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary.
Zsuzsanna DombrádiDepartment of Medical Microbiology, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary.
Anikó BorbásDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary.
Pál HerczeghDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary. herczeghp@gmail.com.
University of Debrecen · HUSemmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance is one of the major challenges in healthcare of our time. To meet this challenge, we designed and prepared guanidine and lipophilic guanidine derivatives of the glycopeptide antibiotic teicoplanin to armed them with activity against the most threatening nosocomial bacteria, multiresistant enterococci. From teicoplanin and its pseudoaglycone, a series of N-terminal guanidine derivatives have been prepared with free and amide C-terminal parts. Six aliphatic and aromatic lipophilic carbodiimides were prepared and used for the synthesis of lipophilic guanidine teicoplanin conjugates. All new N-terminal guanidine antibiotics showed high activity against a standard panel of Gram-positive bacteria. Four selected derivatives displayed excellent antibacterial activity against a series of nosocomial VanA Enterococcus faecium strains.

Indexed as

Anti-Bacterial AgentsDrug Resistance, MicrobialEnterococcus faeciumGlycopeptidesGram-Positive BacteriaGram-Positive Bacterial InfectionsGuanidinesHumansMicrobial Sensitivity TestsTeicoplaninAnti-Bacterial AgentsGlycopeptidesGuanidinesTeicoplanin

Identifiers

PMID32409678
OpenAlexW3024347423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.