Evidence map›Paper›PMID 32409604›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for

Peter S Back, William J O'Shaughnessy, Andy S Moon, Pravin S Dewangan, Xiaoyu Hu, Jihui Sha, James A Wohlschlegel, Peter J Bradley, Michael L Reese

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Two anchoring proteins control daughter apical complex assembly inbioRxiv : the preprint server for biology · 2026
    Article
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  10. Elucidating the Role ofBiomolecules · 2025
    Article
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  12. Review
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  15. Co-dependent formation of thebioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Identification ofmSphere · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Peter S BackMolecular Biology Institute, University of California, Los Angeles, CA 90095.ORCID 0000-0002-4653-8602
William J O'ShaughnessyDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Andy S MoonDepartment of Molecular Microbiology and Immunology, University of California, Los Angeles, CA 90095.ORCID 0000-0003-4559-5530
Pravin S DewanganDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Xiaoyu HuDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Jihui ShaDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
James A WohlschlegelDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Peter J BradleyMolecular Biology Institute, University of California, Los Angeles, CA 90095; pbradley@ucla.edu michael.reese@utsouthwestern.edu.ORCID 0000-0002-8481-0638
Michael L ReeseDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390; pbradley@ucla.edu michael.reese@utsouthwestern.edu.ORCID 0000-0001-9401-9594
University of California, Los Angeles · USThe University of Texas Southwestern Medical Center · US

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0M
Functional Analysis of Novel Components of the Toxoplasma Inner Membrane ComplexR01AI123360 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peter John Bradley · 2017 to 2026
$3.8M
Single Crystal X-ray Diffractometer equipped with Hybrid Pixel Array Detector and In Situ Crystallization Plate Screening CapS10OD025018 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI TOMCHICK, DIANA R. · 2018 to 2018
$453k
NIAID NIH HHS R01 AI123360NIGMS NIH HHS R01 GM089778NIGMS NIH HHS T32 GM007185NIH HHS S10 OD025018
6 · The paper itself

Abstract

Apicomplexan parasites use a specialized cilium structure called the apical complex to organize their secretory organelles and invasion machinery. The apical complex is integrally associated with both the parasite plasma membrane and an intermediate filament cytoskeleton called the inner-membrane complex (IMC). While the apical complex is essential to the parasitic lifestyle, little is known about the regulation of apical complex biogenesis. Here, we identify AC9 (apical cap protein 9), a largely intrinsically disordered component of the

Indexed as

Organelle BiogenesisExtracellular Signal-Regulated MAP KinasesFibroblastsHumansPhosphorylationProtein ConformationProtein TransportProtozoan ProteinsSignal TransductionToxoplasmaToxoplasmosisExtracellular Signal-Regulated MAP KinasesProtozoan Proteinsciliumintrinsically disordered proteinkinasescaffold

Identifiers

PMID32409604
PMCPMC7275706
OpenAlexW3025269549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.