Evidence map›Paper›PMID 32409599›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

l-Arginine sensing regulates virulence gene expression and disease progression in enteric pathogens.

Zelia Menezes-Garcia, Aman Kumar, Wenhan Zhu, Sebastian E Winter, Vanessa Sperandio

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 74 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. EnterohemorrhagiciScience · 2026
    Article
  6. Article
  7. Catabolism of serine enantiomers represses enterohemorrhagicProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Arginine Decarboxylase Gene (Microorganisms · 2026
    Article
  9. Frontiers in cellular and infection microbiology · 2026
    Article
  10. Article
  11. Article
  12. A regulator of amino acid catabolism controlsbioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Arginine at the host-pathogen interface.Infection and immunity · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zelia Menezes-GarciaDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-1600-0289
Aman KumarDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-6962-7851
Wenhan ZhuDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Sebastian E WinterDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-1532-9178
Vanessa SperandioDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390; vanessa.sperandio@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

Quorum sensing regulation of EHEC virulence genesR01AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2003 to 2017
$6.3M
Quorum Sensing Regulation of EHEC Virulence GenesR37AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI VANESSA SPERANDIO · 2018 to 2026
$5.3M
SdiA regulation of EHEC virulenceR01AI077613 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2009 to 2017
$3.4M
Tryptophan derivatives in EHEC pathogenesisR01AI114511 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2015 to 2019
$2.3M
Sugar Regulation of EHEC virulenceR01AI105135 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2013 to 2016
$1.6M
Sugar Regulation of EHEC virulence - A1R56AI105135 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MARESSO, ANTHONY W, SPERANDIO, VANESSA · 2018 to 2018
$499k
Branched Chain Amino Acid Metabolism During AnthraxR21AI146481 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MARESSO, ANTHONY W · 2019 to 2020
$440k
NIAID NIH HHS R01 AI053067NIAID NIH HHS R01 AI077613NIAID NIH HHS R01 AI105135NIAID NIH HHS R01 AI114511NIAID NIH HHS R21 AI146481NIAID NIH HHS R37 AI053067NIAID NIH HHS R56 AI105135
6 · The paper itself

Abstract

Microbiota, host and dietary metabolites/signals compose the rich gut chemical environment, which profoundly impacts virulence of enteric pathogens. Enterohemorrhagic

Indexed as

Gene Expression Regulation, BacterialAnimalsArginineBacterial ProteinsCitrobacter rodentiumEnterobacteriaceae InfectionsEnterohemorrhagic Escherichia coliEscherichia coli InfectionsHumansMiceMice, Inbred C3HVirulenceVirulence FactorsArginineBacterial ProteinsVirulence FactorsarginineArgREHEC

Identifiers

PMID32409599
PMCPMC7275701
OpenAlexW3024817020

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.