Evidence map›Paper›PMID 32409577›Full record

ArticleThe Journal of biological chemistry2020

Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses

Naoko Nakano, Nobuo Sakata, Yuki Katsu, Daiki Nochise, Erika Sato, Yuta Takahashi, Saori Yamaguchi, Yoko Haga, Souichi Ikeno, Mitsuyoshi Motizuki and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Epigenetic Regulations of AhR in the Aspect of Immunomodulation.International journal of molecular sciences · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Naoko NakanoLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.
Nobuo SakataLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.
Yuki KatsuLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.
Daiki NochiseLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.
Erika SatoLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.
Yuta TakahashiLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.
Saori YamaguchiLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.
Yoko HagaLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.
Souichi IkenoLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.
Mitsuyoshi MotizukiDepartment of Biochemistry, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan.
Keigo SanoLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.
Kohei YamasakiLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan.
Keiji MiyazawaDepartment of Biochemistry, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan.
Susumu ItohLaboratory of Biochemistry, Showa Pharmaceutical University, Tokyo, Japan. Electronic address: sitoh@ac.shoyaku.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Accordingly, inhibition of CYP1A1 expression reduces production of carcinogens from PAHs. Although transcription of the

Indexed as

A549 CellsAnimalsAryl Hydrocarbon Receptor Nuclear TranslocatorBenzo(a)pyreneChlorocebus aethiopsCOS CellsCytochrome P-450 CYP1A1Gene ExpressionGene Expression RegulationHEK293 CellsHumansHypoxia-Inducible Factor 1Polycyclic Aromatic HydrocarbonsPyrenesReceptors, Aryl HydrocarbonSignal TransductionARNT protein, humanAryl Hydrocarbon Receptor Nuclear TranslocatorBenzo(a)pyreneCYP1A1 protein, humanCytochrome P-450 CYP1A1Hypoxia-Inducible Factor 1Polycyclic Aromatic HydrocarbonsPyrenesReceptors, Aryl HydrocarbonSmad3 ProteinTransforming Growth Factor betaAhR nuclear translocator (ARNT)aryl hydrocarbon receptor (AhR)benzo[a]pyreneCYP1A1gene regulationhypoxia-inducible factor 1α (HIF-1α)hypoxia-inducible factor (HIF)polycyclic aromatic hydrocarbon (PAH)SmadSmad transcription factortransforming growth factor β (TGF-β)xenobiotic metabolism

Identifiers

PMID32409577
PMCPMC7335805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.