Evidence map›Paper›PMID 32409508›Full record

ArticleeNeuro

Spontaneous Local Calcium Transients Regulate Oligodendrocyte Development in Culture through Store-Operated Ca

Yanfang Rui, Stephanie L Pollitt, Kenneth R Myers, Yue Feng, James Q Zheng

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Regenerative therapy · 2025
    Article
  4. Article
  5. Exploring CaeNeuro · 2024
    Article
  6. SOCE as a regulator of neuronal activity.The Journal of physiology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Characterizing spontaneous CaBiophysical journal · 2022
    Article
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Yanfang RuiDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-8540-3786
Stephanie L PollittDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.
Kenneth R MyersDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.
Yue FengDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-7905-2182
James Q ZhengDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322 james.zheng@emory.edu.ORCID 0000-0002-8093-422X
Emory University · US

Funding

Novel Regulation and Function of the lncRNA Gomafu in Human NeuronsR01NS110110 · NINDS · EMORY UNIVERSITY · PI FENG, YUE · 2019 to 2023
$2.9M
Role of QKI in oligodendroglia and myelin developmentR01NS056097 · NINDS · EMORY UNIVERSITY · PI FENG, YUE · 2007 to 2011
$1.7M
Novel control of CDK5 function in the brainR01NS093016 · NINDS · EMORY UNIVERSITY · PI FENG, YUE · 2015 to 2019
$1.7M
LIM-and-SH3-domain proteins in dendritic spine development and plasticityR21MH108025 · NIMH · EMORY UNIVERSITY · PI ZHENG, JAMES Q · 2016 to 2017
$415k
NIMH NIH HHS R21 MH108025NINDS NIH HHS R01 NS056097NINDS NIH HHS R01 NS093016NINDS NIH HHS R01 NS110110
6 · The paper itself

Abstract

Oligodendrocytes (OLs) insulate axonal fibers for fast conduction of nerve impulses by wrapping axons of the CNS with compact myelin membranes. Differentiating OLs undergo drastic chances in cell morphology. Bipolar oligodendroglial precursor cells (OPCs) transform into highly ramified multipolar OLs, which then expand myelin membranes that enwrap axons. While significant progress has been made in understanding the molecular and genetic mechanisms underlying CNS myelination and its disruption in diseases, the cellular mechanisms that regulate OL differentiation are not fully understood. Here, we report that developing rat OLs in culture exhibit spontaneous Ca

Indexed as

CalciumOligodendrogliaAnimalsCell DifferentiationMyelin SheathNeurogenesisRatsCalciumCa2+ signalinginternal Ca2+ storesoligodendrocytesstore-operated Ca2+ entry

Identifiers

PMID32409508
PMCPMC7438061
OpenAlexW3025257426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.