Evidence map›Paper›PMID 32409472›Full record

ArticleScience (New York, N.Y.)2020

An intrinsic oscillator drives the blood stage cycle of the malaria parasite

Lauren M Smith, Francis C Motta, Garima Chopra, J Kathleen Moch, Robert R Nerem, Bree Cummins, Kimberly E Roche, Christina M Kelliher, Adam R Leman, John Harer and 3 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. Are physiological oscillations physiological?The Journal of physiology · 2026
    Review
  3. Article
  4. Towards an evolutionary baseline model ofbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Review
  7. Malaria: past, present, and future.Signal transduction and targeted therapy · 2025
    Review
  8. Article
  9. Article
  10. Circadian rhythms: pervasive, and often times evasive.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  11. Immune regulation of host energy metabolism and periodicity of malaria parasites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  12. Article
  13. AeLife · 2024
    Article
  14. Melatonin as a Circadian Marker forInternational journal of molecular sciences · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Oscillator death in coupled biochemical oscillators.Mathematics of control, signals, and systems : MCSS · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lauren M SmithDepartment of Biology, Duke University, Durham, NC, USA.ORCID 0000-0002-4892-4478
Francis C MottaDepartment of Mathematical Sciences, Florida Atlantic University, Boca Raton, FL, USA.ORCID 0000-0002-0364-5440
Garima ChopraMalaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID 0000-0003-1893-0567
J Kathleen MochMalaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Robert R NeremDepartment of Mathematical Sciences, Montana State University, Bozeman, MT, USA.ORCID 0000-0002-9125-5855
Bree CumminsDepartment of Mathematical Sciences, Montana State University, Bozeman, MT, USA.ORCID 0000-0002-3097-5277
Kimberly E RocheProgram in Computational Biology and Bioinformatics, Duke University, Durham, NC, USA.ORCID 0000-0002-6541-9393
Christina M KelliherDepartment of Biology, Duke University, Durham, NC, USA.ORCID 0000-0002-4554-1818
Adam R LemanDepartment of Biology, Duke University, Durham, NC, USA.ORCID 0000-0001-9274-8224
John HarerDepartment of Mathematics, Duke University, Durham, NC, USA.
Tomas GedeonDepartment of Mathematical Sciences, Montana State University, Bozeman, MT, USA.ORCID 0000-0001-5555-6741
Norman C WatersMalaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Steven B HaaseDepartment of Biology, Duke University, Durham, NC, USA. steve.haase@duke.edu.ORCID 0000-0001-8127-8992

Funding

Genetics Training Grant-Year 26T32GM007754 · NIGMS · DUKE UNIVERSITY · PI HAASE, STEVEN B · 1985 to 2019
$8.3M
Needle in a haystack: effective search for dynamics across the space of networksR01GM126555 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI MISCHAIKOW, KONSTANTIN · 2017 to 2021
$1.8M
NIGMS NIH HHS R01 GM126555NIGMS NIH HHS T32 GM007754
6 · The paper itself

Abstract

The blood stage of the infection of the malaria parasite

Indexed as

Life Cycle StagesAnimalsCircadian ClocksErythrocytesGene ExpressionGenes, ProtozoanHost-Parasite InteractionsMalaria, FalciparumMicePlasmodium falciparumTranscriptome

Identifiers

PMID32409472
PMCPMC7518718

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.