ArticleScience (New York, N.Y.)2020
The malaria parasite has an intrinsic clock.
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Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59citing papers in PubMed
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Who cites it
59 citing papers in PubMed.
- Behavioral determinants of disease transmission by mosquitoes.Current opinion in insect science · 2026Review
- Identification of PfSR1-MT as melatonin-responsive GPCR-like candidate from the human malaria parasiteCurrent research in microbial sciences · 2026Article
- The importance of meal timing for maintenance of daily rhythms in the gut transcriptome and microbiota.Npj biological timing and sleep · 2026Article
- Under the Cover of Darkness: A Transcriptomic Exploration of Clubroot During the Night.Plant direct · 2026Article
- Circadian considerations in antimicrobials.European journal of clinical pharmacology · 2026Review
- Total Reversal of ALS Confirmed by EMG Normalization, Structural Reconstitution, and Neuromuscular-Molecular Restoration Achieved Through Computerized Brain-Guided Reengineering of the 1927 Nobel Prize Fever Therapy: A Case Report.Diseases (Basel, Switzerland) · 2025Article
- Circadian Biology in Parasites: Beyond Known Mechanisms.Annual review of microbiology · 2025Review
- The critical human pathogen Acinetobacter baumannii exhibits light-regulated circadian rhythms.Communications biology · 2025Article
- Parasite and vector circadian clocks mediate efficient malaria transmission.Nature microbiology · 2025Article
- Circadian rhythms mediate malaria transmission.Nature microbiology · 2025Article
- Timing matters: exploring emergence patterns of two species of trematode furcocercariae from their snail hosts.Folia parasitologica · 2025Article
- Phenotypic and fitness consequences of plasticity in the rhythmic replication of malaria parasites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Circadian metabolic adaptations to infections.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Circadian rhythms: pervasive, and often times evasive.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Time to start taking time seriously: how to investigate unexpected biological rhythms within infectious disease research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Immune regulation of host energy metabolism and periodicity of malaria parasites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Insect circadian plasticity as a proposed target for the expression of parasite extended phenotypes.Npj biological timing and sleep · 2025Review
- Hormones in malaria infection: influence on disease severity, host physiology, and therapeutic opportunities.Bioscience reports · 2024Review
- Melatonin as a Circadian Marker forInternational journal of molecular sciences · 2024Review
- Testing the evolutionary drivers of malaria parasite rhythms and their consequences for host-parasite interactions.Evolutionary applications · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Filipa Rijo-FerreiraDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. joseph.takahashi@utsouthwestern.edu filipa.ferreira@utsouthwestern.edu.ORCID 0000-0002-4003-020X
Victoria A Acosta-Rodriguez *Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-4818-0667
John H Abel *Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-8654-9226
Izabela KornblumDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ines BentoInstituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina Universidade de Lisboa, Lisbon, Portugal.ORCID 0000-0002-1049-1443
Gokhul KilaruDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Elizabeth B KlermanDivision of Sleep Medicine, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7402-3171
Maria M MotaInstituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina Universidade de Lisboa, Lisbon, Portugal.
Joseph S TakahashiDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. joseph.takahashi@utsouthwestern.edu filipa.ferreira@utsouthwestern.edu.ORCID 0000-0003-0384-8878
Funding
TRANSPLANTATION ANALYSIS OF CIRCADIAN RHYTHMS AND AGINGP01AG009975 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BUXTON, ORFEU M · 1991 to 2018
$23.1MInfluence of sleep regularity on circadian rhythms, learning, performance, and moodR01HL128538 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KLERMAN, ELIZABETH B. · 2016 to 2019
$3.6MSleep Duration Required to Restore Performance during Chronic Sleep RestrictionK24HL105664 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI KLERMAN, ELIZABETH B. · 2010 to 2019
$1.8MElucidating the mechanism for malaria rhythmicity: an underlying circadian clock of the parasiteR00GM132557 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RIJO-FERREIRA, FILIPA · 2022 to 2024
$895kAutomatic Control of Propanidid and Propofol Anesthesia-Induced UnconsciousnessF32AG064886 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI ABEL, JOHN HANS · 2019 to 2020
$132kElucidating the mechanism for malaria rhythmicity: an underlying circadian clock of the parasiteK99GM132557 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI RIJO-FERREIRA, FILIPA · 2019 to 2021
$122kNHLBI NIH HHS K24 HL105664NHLBI NIH HHS R01 HL128538NIA NIH HHS F32 AG064886NIA NIH HHS P01 AG009975NIGMS NIH HHS K99 GM132557NIGMS NIH HHS R00 GM132557
Abstract
Malarial rhythmic fevers are the consequence of the synchronous bursting of red blood cells (RBCs) on completion of the malaria parasite asexual cell cycle. Here, we hypothesized that an intrinsic clock in the parasite
Indexed as
AnimalsCircadian RhythmCLOCK ProteinsCuesDarknessEatingErythrocytesFeeding BehaviorFeverGene Expression RegulationHost-Parasite InteractionsMalariaMiceMice, Mutant StrainsPlasmodium chabaudiTranscription, GeneticCLOCK Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.