Evidence map›Paper›PMID 32409134›Full record

ArticleVaccine2020

A prospective study of influenza vaccination and time to pregnancy.

Olivia R Orta, Elizabeth E Hatch, Annette K Regan, Rebecca Perkins, Amelia K Wesselink, Sydney K Willis, Ellen M Mikkelsen, Kenneth J Rothman, Lauren A Wise

Open access · goldAbstract read
In one paragraph

Article in Vaccine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Young Adults' Understanding of Modifiable Risk Factors of Infertility.Women's health reports (New Rochelle, N.Y.) · 2024
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Olivia R OrtaDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA. Electronic address: orta@bu.edu.
Elizabeth E HatchDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Annette K ReganDepartment of Epidemiology & Biostatistics, School of Public Health, Texas A&M University, College Station, TX, USA; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Rebecca PerkinsDepartment of Obstetrics and Gynecology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
Amelia K WesselinkDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Sydney K WillisDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Ellen M MikkelsenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
Kenneth J RothmanDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA; RTI Health Solutions, Research Triangle Park, Durham, NC, USA.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Boston University · USAarhus University Hospital · DKUCLA Health · US

Funding

An internet-based preconception cohort study in North America and DenmarkR01HD086742 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE · 2016 to 2026
$6.7M
Feasibility of an internet-based study of time-to-pregnancy in the United StatesR21HD072326 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WISE, LAUREN A · 2013 to 2014
$337k
NICHD NIH HHS R01 HD086742NICHD NIH HHS R21 HD072326
6 · The paper itself

Abstract

backgroundAlthough pregnancy planners are a priority group for influenza vaccination in the United States, little is known about the extent to which influenza vaccination affects fecundability.

methodsWe analyzed data from Pregnancy Study Online (PRESTO), an ongoing preconception cohort study of North American pregnancy planners. During June 2013 to August 2019, 8654 female participants and 2137 of their male partners completed a baseline questionnaire and were followed until reported pregnancy, fertility treatment initiation, loss to follow-up, or 12 menstrual cycles of attempt time, whichever came first. At baseline, male and female participants reported whether they received an influenza vaccination in the past year and the date of vaccination. We used proportional probabilities regression models to estimate fecundability ratios (FR) and 95% confidence intervals (CI) comparing those who did and did not report influenza vaccination, adjusting for demographics, anthropometrics, behavioral factors, and medical history.

resultsInfluenza vaccination in the past year was more common among female participants than male participants (47% vs. 37%). FRs were 1.04 (95% CI: 0.98-1.10) for female vaccination and 1.03 (95% CI: 0.93-1.14) for male vaccination. Among the 2137 couples with complete data on both partners, for 40% neither partner was vaccinated, 23% had female-only vaccination, 9% had male-only vaccination, and in 28% both partners were vaccinated. Compared with couples in which neither participant was vaccinated, FRs were 1.13 for female-only vaccination (95% CI: 0.99-1.29), 0.94 for male-only vaccination (95% CI: 0.78-1.12), and 1.07 when both partners were vaccinated (95% CI: 0.94-1.21). When restricted to recent vaccination before peak influenza season, results were similar.

conclusionsOur data indicate no adverse effect of influenza vaccination on fecundability.

Indexed as

Influenza, HumanTime-to-PregnancyCohort StudiesFemaleHumansMalePregnancyProspective StudiesVaccinationConceptionCouplesFertilityFluInfluenzaPregnancy

Identifiers

PMID32409134
PMCPMC7360345
OpenAlexW3023063259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.