Evidence map›Paper›PMID 32409017›Full record

ReviewTrends in neurosciences2020

Effects of Exercise on Brain and Cognition Across Age Groups and Health States.

Chelsea M Stillman, Irene Esteban-Cornejo, Belinda Brown, Catherine M Bender, Kirk I Erickson

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07284316 (Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance), which is not on this map. Cited by 221 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 19 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07284316 phase2 / phase3active not recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance: A Randomized Clinical Trial

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2025 to 2027Enrolled100ConditionsCognitive Decline, Subjective Cognitive Impairment, Insulin ResistanceArmsTurmeric extract, Control: Placebo. 500mg gelatin in capsules 2 times a day
3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 19 syntheses or guidelines pooled it.

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161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chelsea M StillmanDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Irene Esteban-CornejoPROFITH 'PROmoting FITness and Health through physical activity' Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Belinda BrownCollege of Science, Health, Engineering, and Education, Murdoch University, Perth, Australia.
Catherine M BenderSchool of Nursing University of Pittsburgh, Pittsburgh, PA, USA.
Kirk I EricksonDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; College of Science, Health, Engineering, and Education, Murdoch University, Perth, Australia. Electronic address: kiericks@pitt.edu.

Funding

Substrates of Threat and Reward Sensitivity and CVD RiskP01HL040962 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 1988 to 2022
$31.1M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
Investigating Gains in Neurocognition in an Intervention Trial of Exercise SupplementR01AG053952 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BURNS, JEFFREY MURRAY, ERICKSON, KIRK I · 2016 to 2020
$27.5M
Rhythm Experience and Africana Culture Trial (REACT)R01AG060741 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2018 to 2024
$4.0M
Influence of Exercise on Neurocognitive Function in Breast CancerR01CA196762 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENDER, CATHERINE M., ERICKSON, KIRK I · 2016 to 2020
$3.0M
Epigenomics of Neurocognitive Function in Breast CancerR01CA221882 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENDER, CATHERINE M., CONLEY, YVETTE P · 2018 to 2022
$2.2M
Influence of Physical Activity and Weight Loss on Brain PlasticityR01DK095172 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2012 to 2016
$2.1M
NCI NIH HHS R01 CA196762NCI NIH HHS R01 CA221882NHLBI NIH HHS P01 HL040962NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG053952NIA NIH HHS R01 AG060741NIDDK NIH HHS R01 DK095172
6 · The paper itself

Abstract

Exercise has been shown to benefit brain structure and function, particularly in aging populations. However, the mechanisms by which exercise exerts its effects, especially in humans, are not fully understood. This review argues that one reason for this knowledge gap is that exercise likely operates through multiple levels of mechanisms. Furthermore, the mechanisms of exercise may vary depending on factors such as age and health state. We discuss the state of evidence at each of three levels of analysis (molecular/cellular, brain structure/function, and mental states and higher-order behaviors) and highlight consistencies across these levels, inconsistencies within them, and knowledge gaps. Lastly, based on these, we speculate about which mechanisms of exercise may be universal across age groups and populations versus those that might be distinct to specific age ranges or populations.

Indexed as

BrainCognitionAgingExerciseHumansbraincognitionexerciselifespanmechanismsphysical activity

Identifiers

PMID32409017
PMCPMC9068803

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.