ArticleAlzheimer's research & therapy2020
The meta-memory ratio: a new cohort-independent way to measure cognitive awareness in asymptomatic individuals at risk for Alzheimer's disease.
Article in Alzheimer's research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Dementia risk factors and biomarkers in subjective cognitive decline: real world evidence from the monza brain health service.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Editorial: To Know or Not to Know: causes and evolution of lack of awareness of cognitive decline in neurodegenerative diseases, volume II.Frontiers in aging neuroscience · 2025Article
- Subjective cognitive decline: Memory complaints, cognitive awareness, and metacognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Awareness of episodic memory and meta-cognitive profiles: associations with cerebrospinal fluid biomarkers at the preclinical stage of the Alzheimer's continuum.Frontiers in aging neuroscience · 2024Article
- Consensus on rapid screening for prodromal Alzheimer's disease in China.General psychiatry · 2024Review
- Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories.Alzheimer's research & therapy · 2023Article
- Measurement of Dimensions of Self-awareness of Memory Function and Their Association With Clinical Progression in Cognitively Normal Older Adults.JAMA network open · 2023Article
- Metacognition, cortical thickness, and tauopathy in aging.Neurobiology of aging · 2022Article
- Differential Patterns of Domain-Specific Cognitive Complaints and Awareness Across the Alzheimer's Disease Spectrum.Frontiers in aging neuroscience · 2022Article
- Subjective Cognitive Decline Is More Accurate When Metamemory Is Better.Frontiers in aging neuroscience · 2022Article
- Pathological correlates of impaired self-awareness of memory function in Alzheimer's disease.Alzheimer's research & therapy · 2021Article
- Episodic Memory Impairment Mediates the Loss of Awareness in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Trajectory of Unawareness of Memory Decline in Individuals With Autosomal Dominant Alzheimer Disease.JAMA network open · 2020Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLack of awareness of cognitive decline (ACD) has been described at the preclinical and prodromal stages of Alzheimer's disease (AD). In this study, we introduced a meta-memory ratio (MMR) and explored how it is associated with neuroimaging AD biomarkers in asymptomatic individuals at risk for AD.
methodFour hundred forty-eight cognitively healthy participants from two cohorts of subjective memory complainers (INSIGHT-PreAD and ADNI) were included. Regression models were used to assess the impact of AD biomarkers on the MMR.
resultIn both cohorts, there was a significant quadratic effect of cerebral amyloidosis on the MMR value. In particular, participants had a high ACD up to the amyloid positivity threshold, above which a decrease of ACD was eventually observed as the amyloid load increased.
conclusionThis nonlinear evolution of ACD in very early AD must be taken into account in clinical care and for trial enrollment as well.
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