ArticleCirculation. Cardiovascular imaging2020
Association Between Sleep Disordered Breathing and Left Ventricular Function: A Cross-Sectional Analysis of the ECHO-SOL Ancillary Study.
Article in Circulation. Cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06626906 (Predictive Value of Sleep Apnea-specific Pulse Transit Time Response for Incident Subclinical Abnormalities in Left Ventricle Structure and Function in Cohort of moderate-to Severe Obstructive Sleep Apnea), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictive Value of Sleep Apnea-specific Pulse Transit Time Response for Incident Subclinical Abnormalities in Left Ventricle Structure and Function in Cohort of moderate-to Severe Obstructive Sleep Apnea
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Cardiac consequences of intermittent hypoxia: a matter of dose? A systematic review and meta-analysis in rodents.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- A novel diastolic dysfunction score: A proposed diagnostic predictor for left ventricular dysfunction in obese population.Narra J · 2025Article
- Analysis of QRS complex morphology in children and adolescents with obstructive sleep apnea syndrome.European journal of pediatrics · 2024Article
- Heart failure with preserved ejection fraction risk is associated with prevalence and severity of obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Obstructive sleep apnea and hypertension-mediated organ damage in nonresistant and resistant hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study.Frontiers in genetics · 2023Article
- Sleep Apnea and Physical Movement During Sleep, But Not Sleep Duration, Are Independently Associated With Progression of Left Ventricular Diastolic Dysfunction: Prospective Hyogo Sleep Cardio-Autonomic Atherosclerosis Cohort Study.Journal of the American Heart Association · 2022Article
- Intermittent Hypoxia-Induced Cardiomyocyte Death Is Mediated by HIF-1 Dependent MAM Disruption.Antioxidants (Basel, Switzerland) · 2022Article
- Response by Genuardi et al to Letter Regarding Article, "Association Between Sleep Disordered Breathing and Left Ventricular Function: a Cross-Sectional Analysis of the ECHO-SOL Ancillary Study".Circulation. Cardiovascular imaging · 2020Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrior studies have found that sleep-disordered breathing (SDB) is common among those with left ventricular (LV) dysfunction and heart failure. Few epidemiological studies have examined this association, especially in US Hispanic/Latinos, who may be at elevated risk of SDB and heart failure.
methodsWe examined associations between SDB and LV diastolic and systolic function using data from 1506 adults aged 18 to 64 years in the Hispanic Community Health Study/Study of Latinos ECHO-SOL Ancillary Study (2011-2014). Home sleep testing was used to measure the apnea-hypopnea index, a measure of SDB severity. Echocardiography was performed a median of 2.1 years later to quantify LV diastolic function, systolic function, and structure. Multivariable linear regression was used to model the association between apnea-hypopnea index and echocardiographic measures while accounting for the complex survey design, demographics, body mass, and time between sleep and echocardiographic measurements.
resultsEach 10-unit increase in apnea-hypopnea index was associated with 0.2 (95% CI, 0.1-0.3) lower E', 0.3 (0.1-0.5) greater E/E' ratio, and 1.07-fold (1.03-1.11) higher prevalence of diastolic dysfunction as well as 1.3 (0.3-2.4) g/m
conclusionsGreater SDB severity was associated with LV hypertrophy and subclinical markers of LV diastolic dysfunction. These findings suggest SDB in Hispanic/Latino men and women may contribute to the burden of heart failure in this population.
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