Evidence map›Paper›PMID 32408830›Full record

ArticleCirculation. Cardiovascular imaging2020

Diffusion Tensor Cardiovascular Magnetic Resonance in Cardiac Amyloidosis.

Zohya Khalique, Pedro F Ferreira, Andrew D Scott, Sonia Nielles-Vallespin, Ana Martinez-Naharro, Marianna Fontana, Phillip Hawkins, David N Firmin, Dudley J Pennell

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Circulation. Cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Cardiac amyloidosis: Innovations in diagnosis and treatment.European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
  4. Review
  5. Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heart.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. A Review of Current and Evolving Imaging Techniques in Cardiac Amyloidosis.Current treatment options in cardiovascular medicine · 2023
    Article
  16. Article
  17. Article
  18. Diffusion-weighted imaging and diffusion tensor imaging of the heartPostepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Zohya KhaliqueCardiovascular Magnetic Resonance Unit, Royal Brompton Hospital Sydney Street, London, United Kingdom (Z.K., P.F.F., A.D.S., S.N.-V., D.N.F., D.J.P.).
Pedro F FerreiraCardiovascular Magnetic Resonance Unit, Royal Brompton Hospital Sydney Street, London, United Kingdom (Z.K., P.F.F., A.D.S., S.N.-V., D.N.F., D.J.P.).
Andrew D ScottCardiovascular Magnetic Resonance Unit, Royal Brompton Hospital Sydney Street, London, United Kingdom (Z.K., P.F.F., A.D.S., S.N.-V., D.N.F., D.J.P.).
Sonia Nielles-VallespinCardiovascular Magnetic Resonance Unit, Royal Brompton Hospital Sydney Street, London, United Kingdom (Z.K., P.F.F., A.D.S., S.N.-V., D.N.F., D.J.P.).
Ana Martinez-NaharroNational Amyloidosis Centre, University College London Royal Free Hospital, United Kingdom (A.M.-N., M.F., P.H.).
Marianna FontanaNational Amyloidosis Centre, University College London Royal Free Hospital, United Kingdom (A.M.-N., M.F., P.H.).
Phillip HawkinsNational Amyloidosis Centre, University College London Royal Free Hospital, United Kingdom (A.M.-N., M.F., P.H.).
David N Firmin *Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital Sydney Street, London, United Kingdom (Z.K., P.F.F., A.D.S., S.N.-V., D.N.F., D.J.P.).
Dudley J Pennell *Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital Sydney Street, London, United Kingdom (Z.K., P.F.F., A.D.S., S.N.-V., D.N.F., D.J.P.).
Royal Brompton Hospital · GBAmyloidosis Foundation · US

Funding

British Heart Foundation FS/18/21/33447British Heart Foundation RG/19/1/34160
6 · The paper itself

Abstract

Background Cardiac amyloidosis (CA) is a disease of interstitial myocardial infiltration, usually by light chains or transthyretin. We used diffusion tensor cardiovascular magnetic resonance (DT-CMR) to noninvasively assess the effects of amyloid infiltration on the cardiac microstructure. Methods DT-CMR was performed at diastole and systole in 20 CA, 11 hypertrophic cardiomyopathy, and 10 control subjects with calculation of mean diffusivity, fractional anisotropy, and sheetlet orientation (secondary eigenvector angle). Results Mean diffusivity was elevated and fractional anisotropy reduced in CA compared with both controls and hypertrophic cardiomyopathy (

Indexed as

Diffusion Tensor ImagingAgedAmyloid Neuropathies, FamilialCardiomyopathiesCardiomyopathy, HypertrophicCase-Control StudiesDiagnosis, DifferentialFemaleHumansImmunoglobulin Light-chain AmyloidosisMaleMiddle AgedMyocardiumPredictive Value of Testsamyloiddiffusion tensor imagingextracellular spacemagnetic resonance imagingmyocardium

Identifiers

PMID32408830
PMCPMC7255887
OpenAlexW3025805006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.