Evidence map›Paper›PMID 32408604›Full record

ReviewBiomedicines2020

Scorpion Venom: Detriments and Benefits.

Shirin Ahmadi, Julius M Knerr, Lídia Argemi, Karla C F Bordon, Manuela B Pucca, Felipe A Cerni, Eliane C Arantes, Figen Çalışkan, Andreas H Laustsen

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 165 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Predictive value of admission blood glucose for early severity stratification in pediatric scorpion envenomation.The journal of venomous animals and toxins including tropical diseases · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Targeted Metabolomics ofJournal of the American Society for Mass Spectrometry · 2025
    Article
  14. Article
  15. Characterization ofToxins · 2025
    Article
  16. Review
  17. Review
  18. Article
  19. LaIT6: A Novel Insect-Selective KMolecules (Basel, Switzerland) · 2025
    Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Shirin AhmadiDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.ORCID 0000-0002-4131-583X
Julius M KnerrDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.ORCID 0000-0003-4770-5342
Lídia ArgemiDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.
Karla C F BordonDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto-São Paulo 14040-903, Brazil.ORCID 0000-0001-6540-2295
Manuela B PuccaDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.ORCID 0000-0003-2594-7068
Felipe A CerniDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.
Eliane C ArantesDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto-São Paulo 14040-903, Brazil.ORCID 0000-0002-6712-6033
Figen ÇalışkanDepartment of Biotechnology and Biosafety, Graduate School of Natural and Applied Sciences, Eşkisehir Osmangazi University, TR-26040 Eşkisehir, Turkey.
Andreas H LaustsenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.ORCID 0000-0001-6918-5574
Technical University of Denmark · DKUniversidade de São Paulo · BREskişehir Osmangazi University · TRUniversidade Federal de Roraima · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scorpion venom may cause severe medical complications and untimely death if injected into the human body. Neurotoxins are the main components of scorpion venom that are known to be responsible for the pathological manifestations of envenoming. Besides neurotoxins, a wide range of other bioactive molecules can be found in scorpion venoms. Advances in separation, characterization, and biotechnological approaches have enabled not only the development of more effective treatments against scorpion envenomings, but have also led to the discovery of several scorpion venom peptides with interesting therapeutic properties. Thus, scorpion venom may not only be a medical threat to human health, but could prove to be a valuable source of bioactive molecules that may serve as leads for the development of new therapies against current and emerging diseases. This review presents both the detrimental and beneficial properties of scorpion venom toxins and discusses the newest advances within the development of novel therapies against scorpion envenoming and the therapeutic perspectives for scorpion toxins in drug discovery.

Indexed as

analgesicsantivenombradykinin potentiating peptidecalcinsfungicideparasiticidepotassium channel toxinsscorpionismscorpion venom

Identifiers

PMID32408604
PMCPMC7277529
OpenAlexW3025541365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.