Evidence map›Paper›PMID 32408504›Full record

ArticleInternational journal of molecular sciences2020

Dual Target Ligands with 4-

Dorota Łażewska, Agnieszka Olejarz-Maciej, David Reiner, Maria Kaleta, Gniewomir Latacz, Małgorzata Zygmunt, Agata Doroz-Płonka, Tadeusz Karcz, Annika Frank, Holger Stark and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
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  7. Article
  8. Article
  9. Superiority of the Triple-Acting 5-HTJournal of medicinal chemistry · 2023
    Article
  10. Review
  11. Salsolinol Protects SH-SY5Y Cells Against MPPNeurochemical research · 2023
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Dorota ŁażewskaDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Str, 30-688 Kraków, Poland.
Agnieszka Olejarz-MaciejDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Str, 30-688 Kraków, Poland.
David ReinerInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.
Maria KaletaDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Str, 30-688 Kraków, Poland.
Gniewomir LataczDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Str, 30-688 Kraków, Poland.
Małgorzata ZygmuntDepartment of Pharmacodynamics, Jagiellonian University Medical College, 9 MedycznaStr, 30-688 Kraków, Poland.
Agata Doroz-PłonkaDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Str, 30-688 Kraków, Poland.
Tadeusz KarczDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Str, 30-688 Kraków, Poland.
Annika FrankInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.
Holger StarkInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.
Katarzyna Kieć-KononowiczDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Str, 30-688 Kraków, Poland.
Jagiellonian University · PLHeinrich Heine University Düsseldorf · DE

Funding

German Research Foundation DFG INST 208/664-1 FUGGNational Science Centre, Poland 2019/03/X/NZ7/00180National Science Centre, Poland UMO-2016/23/B/NZ7/02327
6 · The paper itself

Abstract

Dual target ligands are a promising concept for the treatment of Parkinson's disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with histamine H

Indexed as

AminesAnimalsCatalepsyCell Line, TumorCell ProliferationHaloperidolHEK293 CellsHistamine H3 AntagonistsHumansKineticsLigandsMaleMolecular StructureMonoamine OxidaseMonoamine Oxidase InhibitorsParkinson DiseaseAminesHaloperidolHistamine H3 AntagonistsLigandsMonoamine OxidaseMonoamine Oxidase Inhibitors4-tert-butylphenyl derivativesantagonistsdual-target ligandshistamine H3 receptorinhibitorsmonoamine oxidase Bneurodegenerative diseaseParkinson’s disease

Identifiers

PMID32408504
PMCPMC7279487
OpenAlexW3024415188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.