Evidence map›Paper›PMID 32408270›Full record

ArticleEndocrinology, diabetes & metabolism case reports2020

Coexistence of DIPNECH and carotid body paraganglioma: is it just a coincidence?

J Pedro, F M Cunha, V Neto, V Hespanhol, D F Martins, S Guimarães, A Varela, D Carvalho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, diabetes & metabolism case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

J PedroDepartment of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal.
F M CunhaDepartment of Endocrinology, Diabetes and Metabolism, Centro Hospitalar do Tâmega e Sousa, Penafiel, Portugal.
V NetoDepartment of Pneumology, Centro Hospitalar Universitário de São João, Porto, Portugal.
V HespanholFaculty of Medicine of Universidade do Porto, Porto, Portugal.
D F MartinsFaculty of Medicine of Universidade do Porto, Porto, Portugal.
S GuimarãesDepartment of Pathology, Centro Hospitalar Universitário de São João, Porto, Portugal.
A VarelaDepartment of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal.
D CarvalhoDepartment of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal.
Hospital de São João · PTi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTCentro Hospitalar do Tâmega e Sousa · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

summaryWe describe the case of a 56 year-old woman with the almost simultaneous appearance of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) and a carotid body paraganglioma. Of interest, 6 years earlier, the patient underwent total thyroidectomy due to papillary thyroid carcinoma and, in the meantime, she was submitted to mastectomy to treat an invasive ductal carcinoma of the breast. In order to explain these lesions, an extensive genetic study was performed. Results showed positivity for the presence of the tumor suppressor gene PALB2, whose presence had already been detected in a niece with breast cancer. The patient underwent different procedures to treat the lesions and currently she is symptom-free over 2 years of follow-up. LEARNING POINTS: The presence of two rare neoplasms in a single person should raise the suspicion of a common etiology. To the best of our knowledge, this is the first case that shows the coexistence of DIPNECH and paraganglioma. The contribution of the PALB2 gene in the etiology of these rare neoplasms is a possibility.

Indexed as

2020AdrenalAdultBiopsyBreast cancer*Chromogranin ACT scanCytokeratins*DIPNECH*DyspnoeaFemaleHaematoxylin and eosin stainingHistopathologyImmunohistochemistryLevothyroxineMayMolecular genetic analysisNeuroendocrine tumourNew disease or syndrome: presentations/diagnosis/managementOncologyPapillary thyroid cancerParagangliomaPET scanPortugalPulmonary biopsy*Resection of tumourS-100 protein*SynaptophysinThyroxine (T4)WheezingWhite

Identifiers

PMID32408270
PMCPMC7274547
OpenAlexW3025138874

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.