ArticleNeuroImage2020
XTRACT - Standardised protocols for automated tractography in the human and macaque brain.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
204 citing papers in PubMed, 1 synthesis or guideline pooled it, 325 citations in OpenAlex.
- A systematic review of automated methods to perform white matter tract segmentation.Frontiers in neuroscience · 2024Pooled it
- Reversible white matter changes following a 4-week high phenylalanine exposure in adults with phenylketonuria.Journal of inherited metabolic disease · 2025Trial
- Trial
- Developing an SNR-efficient tensor-valued diffusion encoding protocol for studying brain microstructural changes in neurodegeneration.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Mesocorticolimbic Dopamine-Reward Tract Alterations and the 'Dark Side' of Methamphetamine Addiction.Addiction biology · 2026Article
- A hierarchical framework for cortical and subcortical gray-matter parcellation across rodents, primates, and humans.Nature communications · 2026Article
- Reduced cortical gyrification in type 1 diabetes is associated with white matter integrity loss and cognitive decline.Metabolic brain disease · 2026Article
- Offline Reconstruction of Diffusion MRI Acquisitions for Comparison Between Complex PCA-Based and AI-Based Denoising.Magnetic resonance in medicine · 2026Article
- Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Visuospatial Neglect Caused by Microbleeds in a Patient With Cerebral Amyloid Angiopathy: A Case Report.Brain & NeuroRehabilitation · 2026Article
- Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks.Nature neuroscience · 2026Article
- Microscopy-informed structural connectivity mapping in the in vivo human brain via domain adaptation.bioRxiv : the preprint server for biology · 2026Article
- Automated Segmentation of Brainstem and Subcortical White Matter: Mapping the Deep Tegmental Core with BundleParc.bioRxiv : the preprint server for biology · 2026Article
- Disrupted integration-segregation balance in the intact hemisphere in chronic spatial neglect.Brain structure & function · 2026Article
- Evaluating Unimodal and Multimodal Tracking Strategies for the Reconstruction of Language-related White Matter Tracts.Clinical neuroradiology · 2026Article
- Detection of white matter microstructural changes in patients with systemic lupus erythematosus based on multiple diffusion models and related diffusion metrics.Neural regeneration research · 2026Article
- Article
- Telecommunication-inspired network models of healthy and diseased brains.Scientific reports · 2026Article
- Common Electrophysiology Biomarkers Collected at Home Robustly Track Depression Recovery With Deep Brain Stimulation.medRxiv : the preprint server for health sciences · 2026Article
144 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
Abstract
We present a new software package with a library of standardised tractography protocols devised for the robust automated extraction of white matter tracts both in the human and the macaque brain. Using in vivo data from the Human Connectome Project (HCP) and the UK Biobank and ex vivo data for the macaque brain datasets, we obtain white matter atlases, as well as atlases for tract endpoints on the white-grey matter boundary, for both species. We illustrate that our protocols are robust against data quality, generalisable across two species and reflect the known anatomy. We further demonstrate that they capture inter-subject variability by preserving tract lateralisation in humans and tract similarities stemming from twinship in the HCP cohort. Our results demonstrate that the presented toolbox will be useful for generating imaging-derived features in large cohorts, and in facilitating comparative neuroanatomy studies. The software, tractography protocols, and atlases are publicly released through FSL, allowing users to define their own tractography protocols in a standardised manner, further contributing to open science.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.