Evidence map›Paper›PMID 32407836›Full record

ArticleThe Journal of allergy and clinical immunology2020

Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China.

Ruchong Chen, Ling Sang, Mei Jiang, Zhaowei Yang, Nan Jia, Wanyi Fu, Jiaxing Xie, Weijie Guan, Wenhua Liang, Zhengyi Ni and 26 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 25 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 25 syntheses or guidelines pooled it, 408 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Associations between Serum Interleukins (IL-1BioMed research international · 2022
    Pooled it
  9. Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022
    Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Serum amyloid A concentrations, COVID-19 severity and mortality: An updated systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Pooled it
  17. Pooled it
  18. Pooled it
  19. Pooled it
  20. Pooled it

161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 17 institutions in 1 country.

Ruchong ChenDepartment of Allergy and Clinical Immunology, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Ling SangNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Mei JiangNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Zhaowei YangDepartment of Allergy and Clinical Immunology, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Nan JiaDepartment of Allergy and Clinical Immunology, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Wanyi FuDepartment of Allergy and Clinical Immunology, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Jiaxing XieDepartment of Allergy and Clinical Immunology, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Weijie GuanNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Wenhua LiangNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Zhengyi NiWuhan Jin-yin tan Hospital, Wuhan, Hubei, China.
Yu HuUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Lei LiuShenzhen Third People's Hospital, Shenzhen, China.
Hong ShanThe Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China.
Chunliang LeiGuangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Yixiang PengThe Central Hospital of Wuhan, Wuhan, Hubei, China.
Li WeiWuhan No.1 Hospital, Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, Hubei, China.
Yong LiuChengdu Public Health Clinical Medical Center, Chengdu, Sichuan, China.
Yahua HuHuangshi Central Hospital of Edong Healthcare Group, Affiliated Hospital of Hubei Polytechnic University, Huangshi, Hubei, China.
Peng PengWuhan Pulmonary Hospital, Wuhan, Hubei, China.
Jianming WangTianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China.
Jiyang LiuThe First Hospital of Changsha, Changsha, Hunan, China.
Zhong ChenThe Third People's Hospital of Hainan Province, Sanya, Hainan, China.
Gang LiHuanggang Central Hospital, Huanggang, Hubei, China.
Zhijian ZhengWenling First People's Hospital, Wenling, Zhejiang, China.
Shaoqin QiuThe Third People's Hospital of Yichang, Yichang, Hubei.
Jie LuoAffiliated Taihe Hospital of Hubei University of Medicine, Shiyan, Hubei, China.
Changjiang YeXiantao First People's Hospital, Xiantao, China.
Shaoyong ZhuThe People's Hospital of Huangpi District, Wuhan, China.
Jinping ZhengNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Nuofu ZhangNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Yimin LiNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Jianxing HeNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Jing LiDepartment of Allergy and Clinical Immunology, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: lijing@gird.cn.
Shiyue LiNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: lishiyue@188.com.
Nanshan ZhongNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: nanshan@vip.163.com.
Medical Treatment Expert Group for COVID-19
First Affiliated Hospital of Guangzhou Medical University · CNHubei Polytechnic University · CNCentral Hospital of Wuhan · CNGuangzhou Eighth People's Hospital · CNHuanggang Central Hospital · CNHubei University of Medicine · CNJinyintan Hospital · CNPublic Health Clinical Center of Chengdu · CNSanya Central Hospital · CNSecond Hospital of Yichang · CNShenzhen Third People’s Hospital · CNSun Yat-sen University · CNThe First Hospital of Changsha · CNThe First People's Hospital of Wenling · CNWuhan No.1 Hospital · CNWuhan Pulmonary Hospital · CNWuhan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCrucial roles of hematologic and immunologic responses in progression of coronavirus disease 2019 (COVID-19) remain largely unclear.

objectiveWe sought to address the dynamic changes in hematologic and immunologic biomarkers and their associations with severity and outcomes of COVID-19.

methodsA retrospective study including 548 patients with COVID-19 with clarified outcome (discharged or deceased) from a national cohort in China was performed. Cross-sectional and longitudinal variations were compared and the associations with different severity and outcomes were analyzed.

resultsOn admission, the counts of lymphocytes, T-cell subsets, eosinophils, and platelets decreased markedly, especially in severe/critical and fatal patients. Increased neutrophil count and neutrophils-to-lymphocytes ratio were predominant in severe/critical cases or nonsurvivors. During hospitalization, eosinophils, lymphocytes, and platelets showed an increasing trend in survivors, but maintained lower levels or dropped significantly afterwards in nonsurvivors. Nonsurvivors kept a high level or showed an upward trend for neutrophils, IL-6, procalcitonin, D-dimer, amyloid A protein, and C-reactive protein, which were kept stable or showed a downward trend in survivors. Positive correlation between CD8

conclusionsHematologic and immunologic impairment showed a significantly different profile between survivors and nonsurvivors in patients with COVID-19 with different severity. The longitudinal variations in these biomarkers could serve to predict recovery or fatal outcome.

Indexed as

AdultAgedBetacoronavirusBiomarkersChinaCohort StudiesCoronavirus InfectionsCOVID-19Cross-Sectional StudiesDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedPandemicsBiomarkersCOVID-19Hematologic indicesimmunologic responsesoutcomeseverity

Identifiers

PMID32407836
PMCPMC7212968
OpenAlexW3023125802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.