Evidence map›Paper›PMID 32407716›Full record

ReviewInternational journal for parasitology2020

Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.

Zhee S Wong, Sarah L Sokol Borrelli, Carolyn C Coyne, Jon P Boyle

Open access · hybridAbstract readReview
In one paragraph

Review in International journal for parasitology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Frontiers in microbiology · 2024
    Article
  7. Effects of Ovine Monocyte-Derived Macrophage Infection by Recently IsolatedAnimals : an open access journal from MDPI · 2022
    Article
  8. Review
  9. Key Limitations and New Insights Into theFrontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhee S WongDepartment of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, United States.
Sarah L Sokol BorrelliDepartment of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, United States.
Carolyn C CoyneDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Jon P BoyleDepartment of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: boylej@pitt.edu.
University of Pittsburgh · US

Funding

Comparative and functional genomics of Toxoplasma and Hammondia hammondiR01AI116855 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOYLE, JON P · 2015 to 2024
$3.2M
Finishing multiple genomes in EupathDB using Oxford Nanopore Single Molecule sequencingR21AI154386 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOYLE, JON P · 2020 to 2021
$457k
Molecular mechanisms of Toxoplasma-placenta interactionsR21AI139576 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOYLE, JON P, COYNE, CAROLYN B · 2018 to 2019
$430k
NIAID NIH HHS R01 AI116855NIAID NIH HHS R21 AI139576NIAID NIH HHS R21 AI154386
6 · The paper itself

Abstract

Toxoplasma gondii is remarkably unique in its ability to successfully infect vertebrate hosts from multiple phyla and can successfully infect most cells within these organisms. The infection outcome in each of these species is determined by the complex interaction between parasite and host genotype. As techniques to quantify global changes in cell function become more readily available and precise, new data are coming to light about how (i) different host cell types respond to parasitic infection and (ii) different parasite species impact the host. Here we focus on recent studies comparing the response to intracellular parasitism by different cell types and insights into understanding host-parasite interactions from comparative studies on T. gondii and its close extant relatives.

Indexed as

Host-Parasite InteractionsToxoplasmaToxoplasmosisAnimalsApicomplexaBiological EvolutionCell LineChemokinesCoccidiosisGene ExpressionHost SpecificityHumansImmunityInterferon-gammaMammalsNeosporaChemokinesInterferon-gammaProtein Serine-Threonine KinasesProtozoan ProteinsROP18 protein, Toxoplasma gondiiTumor Suppressor Protein p53ChemokinesHammondia hammondiHost responseNeospora caninumPlacentaToxoplasma gondii

Identifiers

PMID32407716
PMCPMC8281328
OpenAlexW3024306797

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.