Evidence map›Paper›PMID 32407688›Full record

ReviewTrends in biotechnology2020

Intraoperative Bioprinting: Repairing Tissues and Organs in a Surgical Setting.

Yang Wu, Dino J Ravnic, Ibrahim T Ozbolat

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Thiolated Polymers in 3D Bioprinting: Control of Gelation.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Droplet-based bioprinting.Nature reviews. Methods primers · 2025
    Article
  11. Article
  12. Review
  13. Regenerative cell therapy with 3D bioprinting.Science (New York, N.Y.) · 2024
    Article
  14. Review
  15. Article
  16. Silk fibroin-based inks forBioactive materials · 2024
    Article
  17. Tissue Bioprinting: Promise and Challenges.Bioengineering (Basel, Switzerland) · 2023
    Article
  18. An Adhesive Bioink toward Biofabrication under Wet Conditions.Small (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yang WuSchool of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, China; Engineering Science and Mechanics Department, The Pennsylvania State University, State College, PA 16801, USA; The Huck Institutes of the Life Sciences, The Pennsylvania State University, State College, PA 16801, USA.
Dino J RavnicDepartment of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Ibrahim T OzbolatEngineering Science and Mechanics Department, The Pennsylvania State University, State College, PA 16801, USA; The Huck Institutes of the Life Sciences, The Pennsylvania State University, State College, PA 16801, USA; Department of Biomedical Engineering, Penn State University, University Park, PA 16801, USA; Materials Research Institute, Penn State University, University Park, PA 16801, USA. Electronic address: ito1@psu.edu.

Funding

Intraoperative bioprinting of composite tissues with zonal stratification for craniomaxillofacial reconstructionR01DE028614 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI OZBOLAT, IBRAHIM · 2020 to 2024
$2.8M
Spatiotemporal Modulation of Osteogenesis in a 3-D Stromal/Stem Cell ModelR01DE024790 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI HAYES, DANIEL J. · 2015 to 2019
$1.7M
NIDCR NIH HHS R01 DE024790NIDCR NIH HHS R01 DE028614
6 · The paper itself

Abstract

3D bioprinting directly into injured sites in a surgical setting, intraoperative bioprinting (IOB), is an effective process, in which the defect information can be rapidly acquired and then repaired via bioprinting on a live subject. In patients needing tissue resection, debridement, traumatic reconstruction, or fracture repair, the ability to scan and bioprint immediately following surgical preparation of the defect site has great potential to improve the precision and efficiency of these procedures. In this opinion article, we provide the reader with current major limitations of IOB from engineering and clinical points of view, as well as possibilities of future translation of bioprinting technologies from bench to bedside, and expound our perspectives in the context of IOB of composite and vascularized tissues.

Indexed as

BioprintingHumansPrinting, Three-DimensionalTissue EngineeringTissue Scaffoldsbioprinting technologiesclinical translationintraoperative bioprintingsurgery

Identifiers

PMID32407688
PMCPMC7666846

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.