ArticlePLoS genetics2020
The genetic architecture of the maize progenitor, teosinte, and how it was altered during maize domestication.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 40 citations in OpenAlex.
- Do maize chromosomes contribute to genetic variance in proportion to their size in elite populations?The plant genome · 2026Article
- The population genetics of convergent adaptation in maize and teosinte is not locally restricted.eLife · 2025Article
- Genomic variation in weedy and cultivated broomcorn millet accessions uncovers the genetic architecture of agronomic traits.Nature genetics · 2024Article
- Auxins and grass shoot architecture: how the most important hormone makes the most important plants.Journal of experimental botany · 2023Review
- The role of non-additive gene action on gene expression variation in plant domestication.EvoDevo · 2023Article
- Functional Allele Validation by Gene Editing to Leverage the Wealth of Genetic Resources for Crop Improvement.International journal of molecular sciences · 2022Review
- Gradual domestication of root traits in the earliest maize from Tehuacán.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Gene network simulations provide testable predictions for the molecular domestication syndrome.Genetics · 2022Article
- Domestication reshaped the genetic basis of inbreeding depression in a maize landrace compared to its wild relative, teosinte.PLoS genetics · 2021Article
- Selective sorting of ancestral introgression in maize and teosinte along an elevational cline.PLoS genetics · 2021Article
- Sequence modification on demand: search and replace tools for precise gene editing in plants.Transgenic research · 2021Review
- Diversifying maize genomic selection models.Molecular breeding : new strategies in plant improvement · 2021Article
- Developmental genetics of maize vegetative shoot architecture.Molecular breeding : new strategies in plant improvement · 2021Article
- QTL Map of Early- and Late-Stage Perennial Regrowth inFrontiers in plant science · 2021Article
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetics of domestication has been extensively studied ever since the rediscovery of Mendel's law of inheritance and much has been learned about the genetic control of trait differences between crops and their ancestors. Here, we ask how domestication has altered genetic architecture by comparing the genetic architecture of 18 domestication traits in maize and its ancestor teosinte using matched populations. We observed a strongly reduced number of QTL for domestication traits in maize relative to teosinte, which is consistent with the previously reported depletion of additive variance by selection during domestication. We also observed more dominance in maize than teosinte, likely a consequence of selective removal of additive variants. We observed that large effect QTL have low minor allele frequency (MAF) in both maize and teosinte. Regions of the genome that are strongly differentiated between teosinte and maize (high FST) explain less quantitative variation in maize than teosinte, suggesting that, in these regions, allelic variants were brought to (or near) fixation during domestication. We also observed that genomic regions of high recombination explain a disproportionately large proportion of heritable variance both before and after domestication. Finally, we observed that about 75% of the additive variance in both teosinte and maize is "missing" in the sense that it cannot be ascribed to detectable QTL and only 25% of variance maps to specific QTL. This latter result suggests that morphological evolution during domestication is largely attributable to very large numbers of QTL of very small effect.
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