ArticleJournal of applied physiology (Bethesda, Md. : 1985)2020
Exogenous ketosis impacts neither performance nor muscle glycogen breakdown in prolonged endurance exercise.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Effects of Exogenous Ketone Supplementation on Blood Glucose: A Systematic Review and Meta-analysis.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Acute 1,3-Butanediol Co-Ingestion with Carbohydrate Does Not Improve Endurance Performance in Chronically Ketogenic Male Athletes.Nutrients · 2026Trial
- Ketone monoester plus high-dose glucose supplementation before exercise does not affect immediate post-exercise erythropoietin concentrations versus glucose alone.Physiological reports · 2024Trial
- Tolerability and Acceptability of an Exogenous Ketone Monoester and Ketone Monoester/Salt Formulation in Humans.Nutrients · 2023Trial
- Tolerability and Safety of a Novel Ketogenic Ester, Bis-Hexanoyl (R)-1,3-Butanediol: A Randomized Controlled Trial in Healthy Adults.Nutrients · 2021Trial
- A comprehensive review of the physiology and evidence base to guide the use of ergogenic and medical supplements for enhanced cycling performance.Journal of the International Society of Sports Nutrition · 2026Review
- Intermittent exogenous ketosis does not reduce acute mountain sickness during early terrestrial high-altitude acclimatization.European journal of applied physiology · 2026Article
- Ketone Supplementation in Trained and Physically Active Individuals: Effects on Athletic Performance and Metabolic Variables-A Systematic Review.Life (Basel, Switzerland) · 2026Review
- Carbohydrate Ingestion on Exercise Metabolism and Physical Performance.Endocrine reviews · 2026Review
- The science of ketogenic supplements for athletes: boosting endurance, efficiency, and energy metabolism.Nutrition & metabolism · 2025Review
- Acute and Intermittent Exogenous Ketosis to Support Recovery From Exercise and Adaptations to Exercise Training: A Narrative Review.Scandinavian journal of medicine & science in sports · 2025Review
- Divergent Hepatic Outcomes of Chronic Ketone Supplementation: Ketone Salts Preserve Liver Health While Ketone Esters and Precursors Drive Inflammation and Steatosis.Pharmaceuticals (Basel, Switzerland) · 2025Article
- What is a cycling race simulation anyway: a review on protocols to assess durability in cycling.European journal of applied physiology · 2025Review
- High-fat ketogenic diets and ketone monoester supplements differentially affect substrate metabolism during aerobic exercise.American journal of physiology. Cell physiology · 2023Review
- Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism.Nutrients · 2023Review
- Impact of Paleo Diet on Body Composition, Carbohydrate and Fat Metabolism of Professional Handball Players.Nutrients · 2023Article
- Exogenous Ketone Supplements in Athletic Contexts: Past, Present, and Future.Sports medicine (Auckland, N.Z.) · 2022Review
- The janus face of ketone bodies in hypertension.Journal of hypertension · 2022Review
- The effects of endogenously- and exogenously-induced hyperketonemia on exercise performance and adaptation.Physiological reports · 2022Article
- Effect of increased protein intake and exogenous ketosis on body composition, energy expenditure and exercise capacity during a hypocaloric diet in recreational female athletes.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Available evidence indicates that ketone bodies inhibit glycolysis in contracting muscles. Therefore, we investigated whether acute exogenous ketosis by oral ketone ester (KE) intake early in a simulated cycling race can induce transient glycogen sparing by glycolytic inhibition, thereby increasing glycogen availability in the final phase of the event. In a randomized crossover design, 12 highly trained male cyclists completed a simulated cycling race (RACE), which consisted of 3-h intermittent cycling (IMT
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.