Evidence map›Paper›PMID 32406952›Full record

ArticleJournal of medical virology2020

Hypoalbuminemia predicts the outcome of COVID-19 independent of age and co-morbidity.

Jiaofeng Huang, Aiguo Cheng, Rahul Kumar, Yingying Fang, Gongping Chen, Yueyong Zhu, Su Lin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 15 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 15 syntheses or guidelines pooled it, 345 citations in OpenAlex.

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126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jiaofeng HuangDepartment of Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Aiguo ChengDepartment of Critical Care, The Third People's Hospital of Yichang, Yichang, China.
Rahul KumarDepartment of Gastroenterology and Hepatology, Changi General Hospital, Simei, Singapore.ORCID 0000-0002-5092-4821
Yingying FangDepartment of Tuberculosis, The Third People's Hospital of Yichang, Yichang, China.
Gongping ChenDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Yueyong ZhuDepartment of Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.ORCID 0000-0002-0746-4911
Su LinDepartment of Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.ORCID 0000-0001-7517-9859
Fujian Medical University · CNSecond Hospital of Yichang · CNChangi General Hospital · SG

Funding

Chinese National 13th Five-Year Plan's Science and Technology Projects 2017ZX10202201Fujian Medical University Sailing Fund Project 2018QH1047Fujian Province Health Youth Research Project 2019-1 -37
6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) has evolved into a pandemic rapidly. Most of the literature show that the elevated liver enzymes in COVID-19 are of little clinical significance. Lower albumin level is seen in severe COVID-19 and is not parallel to the changes in alanine aminotransferase and aspartate aminotransferase levels. We aimed to explore the impact of hypoalbuminemia in COVID-19. This retrospective cohort study included adult patients with confirmed COVID-19. The relationship between hypoalbuminemia and death was studied using binary logistic analysis. A total of 299 adult patients were included, 160 (53.5%) were males and the average age was 53.4 ± 16.7 years. The median time from the onset of illness to admission was 3 days (interquartile ranges, 2-5). Approximately one-third of the patients had comorbidities. Hypoalbuminemia (<35 g/L) was found in 106 (35.5%) patients. The difference in albumin was considerable between survivors and non-survivors (37.6 ± 6.2 vs 30.5 ± 4.0, P < .001). Serum albumin level was inversely correlated to white blood cell (r = -.149, P = .01) and neutrophil to lymphocyte ratio (r = -.298, P < .001). Multivariate analysis showed the presence of comorbidities (OR, 6.816; 95% CI, 1.361-34.133), lymphopenia (OR, 13.130; 95% CI, 1.632-105.658) and hypoalbuminemia (OR, 6.394; 95% CI, 1.315-31.092) were independent predictive factors for mortality. In conclusion, hypoalbuminemia is associated with the outcome of COVID-19. The potential therapeutic value of albumin infusion in COVID-19 should be further explored at the earliest.

Indexed as

AdultAgedAge FactorsChinaComorbidityCOVID-19Electronic Health RecordsFemaleHospitalizationHumansHypoalbuminemiaLiver DiseasesMaleMiddle AgedMultivariate AnalysisRetrospective StudiesCOVID-19hypoalbuminemiamortalitypredictionrisk factor

Identifiers

PMID32406952
PMCPMC7273060
OpenAlexW3024065428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.