ArticleJournal of biomedical optics2020
Fast pulsatile blood flow measurement in deep tissue through a multimode detection fiber.
Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Monte Carlo simulations of time-resolved blood flow index: times-of-flight beyond ∼1 ns are necessary for brain-dominated measurements.Neurophotonics · 2026Article
- Research on Denoising Methods for Laser Doppler Blood Flow Signals Based on Time-Domain Noise Perception and DWT.Sensors (Basel, Switzerland) · 2026Article
- Optical methods for cuffless blood pressure measurements.Biophotonics discovery · 2026Review
- Assessing liquid light guides in diffuse correlation spectroscopy systems.Biomedical optics express · 2025Article
- Development of a Rotation-Robust PPG Sensor for a Smart Ring.Sensors (Basel, Switzerland) · 2025Article
- Fiber-Based Ultra-High-Speed Diffuse Speckle Contrast Analysis System for Deep Blood Flow Sensing Using a Large SPAD Camera.Biosensors · 2025Article
- Speckle contrast optical spectroscopy for cuffless blood pressure estimation based on microvascular blood flow and volume oscillations.Biomedical optics express · 2025Article
- Non-ergodicity and noise-corrected diffuse speckle contrast analysis in deep tissue blood flow measurement.Biomedical optics express · 2025Article
- Article
- Portable six-channel laser speckle system for simultaneous measurement of cerebral blood flow and volume with potential applications in characterization of brain injury.Neurophotonics · 2025Article
- Diffuse reflectance spectroscopy for optical characterizations of orthotopic head and neck cancer modelsBiomedical optics express · 2024Article
- Novel Metric for Non-Invasive Beat-to-Beat Blood Pressure Measurements Demonstrates Physiological Blood Pressure Fluctuations during Pregnancy.Sensors (Basel, Switzerland) · 2024Article
- A portable optical pulsatile flowmetry demonstrates strong clinical relevance for diabetic foot perfusion assessment.APL bioengineering · 2024Article
- Ultrasound Flow Imaging Study on Rat Brain with Ultrasound and Light Stimulations.Bioengineering (Basel, Switzerland) · 2024Article
- A Multimode Microfiber Specklegram Biosensor for Measurement of CEACAM5 through AI Diagnosis.Biosensors · 2024Article
- Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath-hold maneuver.Neurophotonics · 2024Article
- Diffuse Correlation Spectroscopy: A Review of Recent Advances in Parallelisation and Depth Discrimination Techniques.Sensors (Basel, Switzerland) · 2023Review
- Pressure stimulus study on acupuncture points with multi-channel multimode-fiber diffuse speckle contrast analysis (MMF-DSCA).Biomedical optics express · 2023Article
- SpeckleCam: high-resolution computational speckle contrast tomography for deep blood flow imaging.Biomedical optics express · 2023Article
- Anatomical Modeling and Optimization of Speckle Contrast Optical Tomography.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
significanceNoninvasive in vivo fast pulsatile blood flow measurement in deep tissue is important because the blood flow waveform is correlated with physiological parameters, such as blood pressure and elasticity of blood vessels. Compromised blood flow may cause diseases, such as stroke, foot ulcer, and myocardial ischemia. There is great clinical demand for a portable and cost-effective device for noninvasive pulsatile blood flow measurement.
aimA diffuse-optics-based method, diffuse speckle pulsatile flowmetry (DSPF), was developed for fast measurement (∼300 Hz) of deep tissue blood flow noninvasively. To validate its performance, both a phantom experiment and in vivo demonstration were conducted. APPROACH: Over the past two decades, single-mode fibers have been used as detection fibers in most diffuse-optics-based deep tissue blood flow measurement modalities. We used a multimode (MM) detection fiber with a core size of 200 μm for diffused speckle pattern detection. A background intensity correction algorithm was implemented for speckle contrast calculation. The MM detection fiber helped to achieve a level of deep tissue blood flow measurement similar to that of conventional modalities, such as diffuse correlation spectroscopy and diffuse speckle contrast analysis, but it increases the measurement rate of blood flow to 300 Hz.
resultsThe design and implementation of the DSPF system were introduced. The theory of the background intensity correction for the diffused speckle pattern detected by the MM fiber was explained. A flow phantom was built for validation of the performance of the DSPF system. An in vivo cuff-induced occlusion experiment was performed to demonstrate the capability of the proposed DSPF system.
conclusionsAn MM detection fiber can help to achieve fast (∼300 Hz) pulsatile blood flow measurement in the proposed DSPF method. The cost-effective device and the fiber-based flexible probe increase the usability of the DSPF system significantly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.