Evidence map›Paper›PMID 32406042›Full record

ArticleJournal of molecular neuroscience : MN2020

Association Between PSD95 Gene 3'UTR Single Nucleotide Polymorphism and Risk of Acute Ischemic Stroke in Chinese Han Population.

Ying-Ying Lin, Tong-Ya Yu, Hui Quan, Yu-Juan Chen, Xue-Yuan Liu, Dong-Ya Huang

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ying-Ying LinDepartment of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-7367-3140
Tong-Ya YuDepartment of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Hui QuanDepartment of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Yu-Juan ChenDepartment of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Xue-Yuan LiuDepartment of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. liuxueyuan1962@163.com.
Dong-Ya HuangDepartment of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China. dongyahuang77@126.com.
Tongji University · CNShanghai East Hospital · CN

Funding

Natural Science Foundation of China 81771131Natural Science Foundation of China 81771258Shanghai Science and Technology Committee Project 17411950100Shanghai Science and Technology Committee Project 17411950101
6 · The paper itself

Abstract

To study the association between the 3'UTR single nucleotide polymorphism of PSD95 gene and the risk of acute ischemic stroke (AIS) in Chinese Han population. PSD95 gene 3'UTR rs191350575, rs314254, rs58197058, rs314253, rs314252, rs188777, rs11652753, rs79715480, and rs13331 genotypes of a total of 280 AIS patients and 280 healthy controls were analyzed. The prognosis outcomes of all AIS patients were analyzed after 3 years of follow-up. The risk of AIS in the rs58197058 locus A allele was 1.76 times higher than the G allele (95%CI 1.53-1.92, p < 0.01). The rs314252 locus A allele carrier was 1.29 times more likely to develop AIS than the G allele (95%CI 1.14-1.45, p < 0.01). The rs13331 locus A allele was a high-risk factor for ASI (adjusted OR = 1.18, 95%CI 1.05-1.33, p = 0.01). The interaction model between Alcohol, DM, Hypertension, rs58197058, and rs314252 predicted the highest accuracy of AIS, with a corresponding sensitivity of 75.36%, specificity of 85.00%, and cross-validation consistency (CVC) of 10/10 (p < 0.01). There was a significant correlation between rs58197058, rs314252, and rs13331 SNPs and plasma FG, TC, HDL-c, and LDL-c levels in AIS patients. The PSD95 gene 3'UTR rs58197058, rs314252, and rs13331 SNPs are associated with the occurrence and prognosis of Chinese Han AIS patients.

Indexed as

Polymorphism, Single Nucleotide3' Untranslated RegionsAdultAgedAged, 80 and overChinaDisks Large Homolog 4 ProteinFemaleHumansIschemic StrokeMaleMiddle Aged3' Untranslated RegionsDisks Large Homolog 4 ProteinDLG4 protein, humanAcute ischemic strokeProgression-free survivalPSD95 geneSingle nucleotide polymorphism

Identifiers

PMID32406042
OpenAlexW3025127858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.