Evidence map›Paper›PMID 32406013›Full record

ReviewCurrent nutrition reports2020

Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry.

Sabrina Mörkl, Mary I Butler, Anna Holl, John F Cryan, Timothy G Dinan

Erratum issuedOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current nutrition reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 154 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 11 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 11 syntheses or guidelines pooled it, 321 citations in OpenAlex.

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  17. PsychobioticFrontiers in immunology · 2023
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94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sabrina MörklAPC Microbiome Ireland, University College Cork, Cork, Ireland. sabrina.moerkl@medunigraz.at.ORCID 0000-0001-5034-6358
Mary I ButlerAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Anna HollAPC Microbiome Ireland, University College Cork, Cork, Ireland.
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Timothy G DinanAPC Microbiome Ireland, University College Cork, Cork, Ireland.
University College Cork · IEMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewProbiotics are living bacteria, which when ingested in adequate amounts, confer health benefits. Gut microbes are suggested to play a role in many psychiatric disorders and could be a potential therapeutic target. Between the gut and the brain, there is a bi-directional communication pathway called the microbiota-gut-brain axis. The purpose of this review is to examine data from recent interventional studies focusing on probiotics and the gut-brain axis for the treatment of depression, anxiety and schizophrenia. RECENT

findingsProbiotics are likely to improve depression but not schizophrenia. Regarding anxiety, there is only one trial which showed an effect of a multispecies probiotic. However, determinants like the duration of treatment, dosage and interactions have not been thoroughly investigated and deserve more scientific attention. Microbiome-based therapies such as probiotics could be cautiously recommended for depression to enhance beneficial bacteria in the gut and to improve mood through the gut-brain axis.

Indexed as

Gastrointestinal MicrobiomeProbioticsAnimalsBrainHumansMental DisordersAnxietyDepressionGut microbiotaMicrobiota-gut-brain axisProbioticsPsychiatrySchizophreniaVagal nerve

Identifiers

PMID32406013
PMCPMC7398953
OpenAlexW3025080937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.