ArticleAnnals of surgical oncology2021
Patterns of Metastasis in Merkel Cell Carcinoma.
Article in Annals of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Merkel Cell Carcinoma 2025.The Journal of dermatology · 2025Guideline
- Merkel-cell carcinoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up.ESMO open · 2024Guideline
- A rare case of metastatic Merkel cell carcinoma presenting without a primary cutaneous lesion: A case report.Medicine · 2026Article
- Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.The Journal of clinical investigation · 2026Article
- General health versus tumor stage: determinants of survival in Merkel cell carcinoma assessed by sentinel lymph node biopsy.Journal of cancer research and clinical oncology · 2026Article
- Intracardiac and Transesophageal Echocardiography-Guided Biopsy of a Large Epicardial Mass.JACC. Case reports · 2026Article
- Prognostic value of different immunohistopathological patterns and Ki67 proliferation index for Merkel cell carcinoma.Head & face medicine · 2025Article
- Distant Metastasis of Merkel Cell Carcinoma: A Descriptive Study.Dermatology practical & conceptual · 2025Article
- Review
- De-Escalating Surgery in Merkel Cell Carcinoma With Clinical Nodal Disease.Journal of surgical oncology · 2025Article
- Merkel cell polyomavirus in lung carcinogenesis: evidence and controversy.Frontiers in oncology · 2025Review
- The Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2024Article
- Survival outcomes in patients withFrontiers in oncology · 2024Article
- Review of Merkel cell carcinoma with solitary pancreatic metastases mimicking primary neuroendocrine tumor of the pancreas.Clinical journal of gastroenterology · 2023Review
- Metastatic Merkel Cell Carcinoma Within a Cortisol-producing Adrenal Adenoma.JCEM case reports · 2023Article
- Large Intestinal Obstruction and Perforation From Metastatic Merkel Cell Carcinoma: A Case Report.Cureus · 2023Article
- m6A modification of mRNA in skin diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Nationwide multidisciplinary consensus on the clinical management of Merkel cell carcinoma: a Delphi panel.Journal for immunotherapy of cancer · 2022Article
- Survival outcomes and epidemiology of Merkel cell carcinoma of the lower limb and hip: A Surveillance, Epidemiology, and End Results analysis 2000-2018.JAAD international · 2022Article
- Merkel cell carcinoma brain metastasis with radiological findings mimicking primary CNS lymphoma: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMerkel cell carcinoma (MCC) is a cutaneous neuroendocrine malignancy with a propensity for regional and distant spread. Because of the relative infrequency of this disease, the patterns of metastasis in MCC are understudied.
methodsPatients with American Joint Committee on Cancer (8th edition) stage I-IV MCC treated at our institution were identified (1/1/2008-2/28/2018). The first site of metastasis was classified as regional [regional lymph node (LN) basin, in-transit] or distant. Distant metastasis-free (DMFS) and MCC-specific (MSS) survival were estimated.
resultsOf 133 patients, 64 (48%) had stage I, 13 (10%) stage II, 48 (36%) stage III, and 8 (6%) stage IV disease at presentation. The median follow-up time in patients who remained alive was 36 (interquartile range 20-66) months. Regional or distant metastases developed in 78 (59%) patients. The first site was regional in 87%, including 73% with isolated LN involvement, and distant in 13%. Thirty-seven (28%) patients eventually developed distant disease, which most commonly involved the abdominal viscera (51%) and distant LNs (46%) first. The lung (0%) and brain (3%) were rarely the first distant sites. Stage III MCC at presentation was significantly associated with worse DMFS (hazard ratio 4.87, P = 0.001) and stage IV disease with worse MSS (hazard ratio 6.30, P = 0.002).
conclusionsRegional LN metastasis is the most common first metastatic event in MCC, confirming the importance of nodal evaluation. Distant disease spread appears to have a predilection for certain sites. Understanding these patterns could help to guide surveillance strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.