Evidence map›Paper›PMID 32405926›Full record

ArticleCardiovascular engineering and technology2020

Long-Term Venovenous Connection for Extracorporeal Carbon Dioxide Removal (ECCO

N B Steuer, K Hugenroth, T Beck, J Spillner, R Kopp, S Reinartz, T Schmitz-Rode, U Steinseifer, G Wagner, J Arens

Open access · hybridAbstract readValidation Study

In one paragraph

Article in Cardiovascular engineering and technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

1.1field-weighted citation impact, top 22% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

Inflow from a Cardiopulmonary Assist System to the Pulmonary Artery and Its Implications for Local Hemodynamics-a Computational Fluid Dynamics Study.Journal of cardiovascular translational research · 2023
Article
Oxygenation performance assessment of an artificial lung in different central anatomic configurations.The International journal of artificial organs · 2023
Article
In Vitro and In Vivo Feasibility Study for a Portable VV-ECMO and ECCOMembranes · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

N B SteuerDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany. steuer@ame.rwth-aachen.de.ORCID 0000-0003-1927-6456

K HugenrothDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.

T BeckDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.

J SpillnerClinic for Cardiothoracic Surgery, University Hospital RWTH Aachen, Aachen, Germany.

R KoppDepartment of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany.

S ReinartzDepartment of Radiology, University Hospital RWTH Aachen, Aachen, Germany.

T Schmitz-RodeInstitute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.

U SteinseiferDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.

G WagnerDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.

J ArensDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.

RWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCurrently used cannulae for extracorporeal carbon dioxide removal (ECCO

methodsA reference model was selected for computational fluid dynamics, on the basis of the analysis of imaging data. Initially, a sensitivity analysis regarding recirculation was conducted using as variables: blood flow, the distance of drainage and return to the iliocaval junction, as well as the diameter and position of the grafts. Subsequently, the connection was optimized regarding recirculation and the WSS was evaluated. We validated the simulations in a silicone model traversed by dyed fluid.

resultsThe simulations were in good agreement with the validation measurements (mean deviation 1.64%). The recirculation ranged from 32.1 to 0%. The maximum WSS did not exceed 5.57 Pa. The position and diameter of the return graft show the highest influence on recirculation. A correlation was ascertained between recirculation and WSS. Overall, an inflow jet directed at a vessel wall entails not only high WSS, but also a flow separation and thereby an increased recirculation. Therefore, return grafts aligned to the vena cava are crucial.

conclusionIn conclusion, a connection without recirculation could be feasible and therefore provides a promising option for a long-term ECCO

Indexed as

Blood Vessel Prosthesis ImplantationExtracorporeal Membrane OxygenationModels, CardiovascularBiomarkersBlood Vessel ProsthesisCarbon DioxideComputer SimulationFeasibility StudiesHemodynamicsHumansIliac VeinNumerical Analysis, Computer-AssistedProsthesis DesignTime FactorsBiomarkersCarbon DioxideAnastomosisArtificial lungCannulationComputational fluid dynamics (CFD)Extracorporeal carbon dioxide removal (ECCO2R)Extracorporeal life support (ECLS)Recirculation

Identifiers

PMID32405926

DOI10.1007/s13239-020-00466-y

PMCPMC7385029

OpenAlexW3025315714

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.