Evidence map›Paper›PMID 32405692›Full record

ArticleThe Journal of membrane biology2020

The Effect of KcsA Channel on Lipid Bilayer Electroporation Induced by Picosecond Pulse Trains.

Jingchao Tang, Jialu Ma, Lianghao Guo, Kaicheng Wang, Yang Yang, Wenfei Bo, Lixia Yang, Haibo Jiang, Zhe Wu, Baoqing Zeng and 1 more

Abstract read
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In one paragraph

Article in The Journal of membrane biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jingchao TangSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Jialu MaSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Lianghao GuoSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Kaicheng WangSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Yang YangSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Wenfei BoSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Lixia YangSchool of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore.
Haibo JiangChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan, China.
Zhe WuSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Baoqing ZengSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Yubin GongSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. ybgong@uestc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membrane proteins are the major component of plasma membranes, and they play crucial roles in all organisms. To understand the influence of the presence of KcsA channel on cell membrane electroporation induced by picosecond pulse trains (psPT), in this paper, the electroporation of KcsA membrane protein system and bare lipid bilayer system (POPC) with the applied psPT are simulated using molecular dynamics (MD) method. First, we find that the average pore formation time of the KcsA system is longer than the bare system with the applied psPT. In the KcsA system, water protrusions appear more slowly. Then, the system size effects of psPT in the MD simulations are investigated. When the system size decreases, the average pore formation time of small KcsA membrane protein system is shorter than the bare system with the applied psPT. It is found that the psPT makes the protein fluctuation of small system increase greatly; meanwhile the instability of protein disturbs the water and then affects the water protrusion appearance time. Furthermore, it shows that the protein fluctuation of constant electric field is smaller than that of psPT and no field, and protein fluctuation increases with the psPT repetition frequency increasing.

Indexed as

Bacterial ProteinsElectricityElectroporationLipid BilayersMembrane ProteinsModels, MolecularModels, TheoreticalMolecular ConformationPotassium ChannelsStructure-Activity RelationshipBacterial ProteinsLipid BilayersMembrane ProteinsPotassium Channelsprokaryotic potassium channelBare lipid bilayerElectroporationKcsA membrane protein systemMolecular dynamicsPicosecond pulse trains

Identifiers

PMID32405692

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.