ArticleBiological trace element research2021
Study of Essential and Toxic Metal Imbalances in the Scalp Hair of Thyroid Cancer Patients in Comparison with Healthy Donors.
Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- The multifaceted role of hair as a biospecimen: recent advances in precision medicine and forensic science.Experimental & molecular medicine · 2025Review
- Association between Heavy Metals and Trace Elements in Cancerous and Non-cancerous Tissues with the Risk of Colorectal Cancer Progression in Northwest China.Biological trace element research · 2024Article
- Article
- The Diagnostic Value of Trace Metal Concentrations in Hair in Carotid Artery Disease.Journal of clinical medicine · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid cancer is among the most common type of head and neck cancer; diet, age, gender and environmental factors play vital roles in its malignancy. The present study was carried out to assess the imbalances in the contents of trace metals due to onset and progression of thyroid cancer. Scalp hair was used as matrix for the evaluation of toxic and trace metals. Quantification of the metals was done through atomic absorption spectrometry. In comparison with healthy subjects, the thyroid cancer patients revealed significantly higher median levels of Mn (71%), Co (64%), Cr (55%), K (49%), Fe (45%), Mg (42%), Pb (36%), Na (30%), and Ni (26%), while the median level of Zn was considerably lower in the patients. The correlation coefficients among the metals in the patients demonstrated significantly different communal relationships compared with the healthy counterparts. Multivariate methods exhibited noticeably dissimilar apportionment among the metals in the patients than the controls. Significant disparities in the metal levels were also noticed for various types (anaplastic thyroid cancer, follicular thyroid cancer, papillary thyroid cancer, and medullary thyroid cancer) as well as stages (I, II, III, and IV) among the thyroid cancer patients. Majority of the metals revealed perceptible disparities in their contents based on gender, habitat, dietary habits, and smoking habits of the patients and controls. Overall, the study showed significantly divergent distribution and associations of the essential and toxic metal levels in the scalp hair of the patients in comparison with the levels in controls.
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