Evidence map›Paper›PMID 32405683›Full record

ReviewHNO2020

[Spectroscopic investigation of the middle ear mucosa].

T Berg, A Kluge, G Steiner, T Zahnert, M Neudert

Abstract readReview
PubMed Publisher
In one paragraph

Review in HNO, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Comparison of the Impacts of Different Middle Ear Mucosal Conditions on Type I Tympanoplasty Outcomes.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

T BergEar Research Center Dresden - ERCD an der, Klinik und Poliklinik für HNO-Heilkunde, Kopf- und Hals-Chirurgie, der medizinischen Fakultät Carl Gustav Carus der TU Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland. theresa.berg@uniklinikum-dresden.de.
A KlugeEar Research Center Dresden - ERCD an der, Klinik und Poliklinik für HNO-Heilkunde, Kopf- und Hals-Chirurgie, der medizinischen Fakultät Carl Gustav Carus der TU Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland.
G SteinerArbeitsgruppe Klinisches Sensoring und Monitoring, TU Dresden, Medizinische Fakultät Carl Gustav Carus, Fetscherstraße 74, 01307, Dresden, Deutschland.
T ZahnertEar Research Center Dresden - ERCD an der, Klinik und Poliklinik für HNO-Heilkunde, Kopf- und Hals-Chirurgie, der medizinischen Fakultät Carl Gustav Carus der TU Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland.
M NeudertEar Research Center Dresden - ERCD an der, Klinik und Poliklinik für HNO-Heilkunde, Kopf- und Hals-Chirurgie, der medizinischen Fakultät Carl Gustav Carus der TU Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland.
TU Dresden · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe middle ear mucosa (MEM) plays a central role in the middle ear due to its function of providing regular ventilation. To date, assessment of the state of the MEM is only possible subjectively by the surgeon. An objective characterization of the state of the MEM is desirable.

objectiveThe aim of this study was to enable objective characterization of the MEM and test infrared (IR) spectroscopy as a possible diagnostic tool for clinical use. MATERIALS AND

methodsDuring middle ear surgery, 48 MEM samples were collected and divided into four groups according to clinical appearance: group I: normal MEM; group II: sclerotic MEM; group III: inflammatory thickened MEM; group IV: granulated MEM. After collection, samples were analyzed by IR spectroscopy to identify characteristic IR spectra.

resultsIn the supervised analysis of the selected images, the biochemical differences representing the decisive factors for classification into groups I to IV were characterized. The differences in amide bands, carbohydrates, lipids, and proteins permit reliable separation of the clinical categories.

conclusionSpectroscopic investigations enable objective characterization of the MEM. Conclusions regarding biochemical differences make it possible to weigh up treatment options. Routine use of IR spectroscopy in the operating theater requires histopathological comparison and an extended dataset with reference values of the individual groups.

Indexed as

Ear, MiddleHumansMucous MembraneSpectrum AnalysisGranulation tissueInflammationPrognostic factorsSclerosisSpectrum analysis

Identifiers

PMID32405683
OpenAlexW3025855492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.