ArticleKidney international reports2020
A Precision Medicine Approach Uncovers a Unique Signature of Neutrophils in Patients With Brushite Kidney Stones.
Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Neutrophil Secretory Proteins Inhibit Calcium Oxalate Crystallisation and Crystal Growth, but Promote Crystal Aggregation.Immunology · 2026Article
- Neutrophil Extracellular Traps Promote the Formation of Canine Dental Calculus.Veterinary sciences · 2026Article
- Calcium Phosphate Nephrolithiasis: A Comprehensive Review.Kidney medicine · 2026Review
- Sex-Specific Associations Between Hyperuricemia and Kidney Stone Disease in a Large Taiwanese Cohort.International journal of medical sciences · 2026Article
- Cooling-induced brushite crystallization in urine as a predictive risk marker for calcium kidney stone recurrence.Urolithiasis · 2025Article
- Effects of calcium oxalate crystals on neutrophil cellular proteome and functions: implications for nephrolithiasis.Cell communication and signaling : CCS · 2025Article
- Neutrophils as mediators of the association between lipid accumulation product and kidney stones, but not for recurrent kidney stones in US adults.Urolithiasis · 2025Article
- Recent developments in the study of cellular inflammation in the papillae of stone formers.Urolithiasis · 2025Review
- Renal papillary tip biopsy in stone formers: a review of clinical safety and insights.Urolithiasis · 2024Review
- Cell death‑related molecules and targets in the progression of urolithiasis (Review).International journal of molecular medicine · 2024Review
- Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Farnesoid X receptor prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease.American journal of physiology. Renal physiology · 2023Article
- A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease.Nature communications · 2023Article
- Integrated Cytometry With Machine Learning Applied to High-Content Imaging of Human Kidney Tissue for In Situ Cell Classification and Neighborhood Analysis.Laboratory investigation; a journal of technical methods and pathology · 2023Article
- Stone Morphology Distinguishes Two Pathways of Idiopathic Calcium Oxalate Stone Pathogenesis.Journal of endourology · 2022Article
- Review
- Increased Urinary Leukocyte Esterase Distinguishes Patients With Brushite Kidney Stones.Kidney international reports · 2021Article
- Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- The Indiana O'Brien Center for Advanced Renal Microscopic Analysis.American journal of physiology. Renal physiology · 2021Review
- Using micro computed tomographic imaging for analyzing kidney stones.Comptes rendus. Chimie (Print) · 2021Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
introductionWe have previously found that papillary histopathology differs greatly between calcium oxalate and brushite stone formers (SF); the latter have much more papillary mineral deposition, tubular cell injury, and tissue fibrosis.
methodsIn this study, we applied unbiased orthogonal
resultsBrushite SF did not differ from CaOx SF with respect to metabolic risk factors for stones but did exhibit increased tubule plugging in their papillae. Brushite SF had upregulation of inflammatory pathways in papillary tissue and increased neutrophil markers in stone matrix compared with those with CaOx stones. Large-scale 3-dimensional tissue cytometry on renal papillary biopsies showed an increase in the number and density of neutrophils in the papillae of patients with brushite versus CaOx, thereby linking the observed inflammatory signatures to the neutrophils in the tissue. To explain how neutrophil proteins appear in the stone matrix, we measured neutrophil extracellular trap (NET) formation-NETosis-and found it significantly increased in the papillae of patients with brushite stones compared with CaOx stones.
conclusionWe show that increased neutrophil infiltration and NETosis is an unrecognized factor that differentiates brushite and CaOx SF and may explain the markedly increased scarring and inflammation seen in the papillae of patients with brushite stones. Given the increasing prevalence of brushite stones, the role of neutrophil activation in brushite stone formation requires further study.
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