ArticleACS macro letters2019
Chemical Approaches to Dynamically Modulate the Properties of Synthetic Matrices.
Article in ACS macro letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Dual-Dynamic Covalently Cross-Linked Polyglycerol Hydrogels for Tumor Spheroid Culture.Biomacromolecules · 2025Article
- Reversible Solubility Switching of a Polymer Triggered by Visible-Light Responsive Azobenzene Photochromism with Negligible Thermal Relaxation.Macromolecular rapid communications · 2024Article
- The third dimension of tumor microenvironment-The importance of tumor stroma in 3D cancer models.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Influence of Backbone Regioregularity on the Optoelectronic and Mechanical Response of Conjugated Polyelectrolyte-Based Hydrogels.The journal of physical chemistry. B · 2023Article
- Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity.Signal transduction and targeted therapy · 2021Review
- Proteinaceous Hydrogels for Bioengineering Advanced 3D Tumor Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Epithelial-Mesenchymal Transition Drives Three-Dimensional Morphogenesis in Mammalian Early Development.Frontiers in cell and developmental biology · 2021Article
- Active biomaterials for mechanobiology.Biomaterials · 2021Review
- Microrheology for biomaterial design.APL bioengineering · 2020Review
- Stimuli-responsive hydrogels for manipulation of cell microenvironment: From chemistry to biofabrication technology.Progress in polymer science · 2019Article
- Genetically Encoded Photocleavable Linkers for Patterned Protein Release from Biomaterials.Journal of the American Chemical Society · 2019Article
- Tunable hydrogels for controlling phenotypic cancer cell states to model breast cancer dormancy and reactivation.Biomaterials · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
As knowledge about the dynamic nature of tissues within the human body has increased, the need for cell culture models that mimic the properties of these dynamic microenvironments has grown. Hydrogels are useful platforms for investigating cellular responses to microenvironment cues in disease and regeneration processes and recently have been designed to contain dynamic bonds to regulate the mechanical and biochemical properties of the matrix in three-dimensional cell culture applications. In this Viewpoint, we highlight recent advances in developing hydrogels with dynamic properties for modeling aspects of human tissues, providing control over the properties of the synthetic matrix on multiple length and time scales, and their application for understanding or directing cell response. We conclude by discussing how orthogonal chemistries can be utilized to design dynamic hydrogel platforms for controlling both the mechanical and biochemical environment, affording opportunities to investigate more complex questions associated with disease progression and tissue regeneration.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.