Evidence map›Paper›PMID 32405433›Full record

ArticleMRS advances2020

RNA Delivery via DNA-Inspired Janus Base Nanotubes for Extracellular Matrix Penetration.

Ian Sands, Jinhyung Lee, Wuxia Zhang, Yupeng Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MRS advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ian SandsDepartment of Engineering, University of Connecticut, Storrs, CT.
Jinhyung LeeDepartment of Engineering, University of Connecticut, Storrs, CT.
Wuxia ZhangDepartment of Engineering, University of Connecticut, Storrs, CT.
Yupeng ChenDepartment of Engineering, University of Connecticut, Storrs, CT.

Funding

Supplement: Developing Nanomaterial Platform for Intra-Cartilage Delivery of RNA Therapeutics against Joint DiseasesR01AR072027 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI CHEN, YUPENG · 2017 to 2022
$2.3M
Growth Plate Cartilage Repair via Novel Matrilin3/Rosette Nanotube Hybrid MatrixR03AR069383 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI CHEN, YUPENG · 2016 to 2018
$242k
NIAMS NIH HHS R01 AR072027NIAMS NIH HHS R03 AR069383
6 · The paper itself

Abstract

RNA delivery into deep tissues with dense extracellular matrix (ECM) has been challenging. For example, cartilage is a major barrier for RNA and drug delivery due to its avascular structure, low cell density and strong negative surface charge. Cartilage ECM is comprised of collagens, proteoglycans, and various other noncollagneous proteins with a spacing of 20nm. Conventional nanoparticles are usually spherical with a diameter larger than 50-60nm (after cargo loading). Therefore, they presented limited success for RNA delivery into cartilage. Here, we developed Janus base nanotubes (JBNTs, self-assembled nanotubes inspired from DNA base pairs) to assemble with small RNAs to form nano-rod delivery vehicles (termed as "Nanopieces"). Nanopieces have a diameter of ~20nm (smallest delivery vehicles after cargo loading) and a length of ~100nm. They present a novel breakthrough in ECM penetration due to the reduced size and adjustable characteristics to encourage ECM and intracellular penetration.

Identifiers

PMID32405433
PMCPMC7220124

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.