ArticleEvolution, medicine, and public health2019
Human milk sIgA antibody in relation to maternal nutrition and infant vulnerability in northern Kenya.
Article in Evolution, medicine, and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants.Nature communications · 2021Trial
- Maternal consumption of urbanized diet compromises early-life health in association with gut microbiota.Gut microbes · 2025Review
- Dual Behavioral-Physiological Buffering of Mothers' Milk Facilitates Drought Adaptability of Pastoralists and Agropastoralists in Northern Kenya.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- No relationship found between dental fluctuating asymmetry, birthweight, and birth term in two modern North American samples.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Human milk immune factors, maternal nutritional status, and infant sex: The INSPIRE study.American journal of human biology : the official journal of the Human Biology Council · 2023Article
- Human milk lactoferrin variation in relation to maternal inflammation and iron deficiency in northern Kenya.American journal of human biology : the official journal of the Human Biology Council · 2022Article
- The role of exclusive breastfeeding on sIgA and lactoferrin levels in toddlers suffering from Acute Respiratory Infection: A cross-sectional study.Annals of medicine and surgery (2012) · 2022Article
- Oropharyngeal administration of mother's own milk influences levels of salivary sIgA in preterm infants fed by gastric tube.Scientific reports · 2022Article
- Tradeoffs in milk immunity affect infant infectious disease risk.Evolution, medicine, and public health · 2022Article
- The Breast Milk Immunoglobulinome.Nutrients · 2021Review
- IgA and FcαRI: Versatile Players in Homeostasis, Infection, and Autoimmunity.ImmunoTargets and therapy · 2020Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe maternal buffering hypothesis posits that human lactation biology can buffer milk against the mild-to-moderate malnutrition that occurred routinely in evolutionary history through the mobilization of maternal body reserves. This perspective may provide insights for understanding human milk immune content variation, such as milk sIgA, which protects infants' intestines from microbial colonization and prevents diarrheal disease.
objectiveTo investigate how maternal delivery of sIgA to milk may vary in a way that can buffer milk against maternal malnutrition, while taking into consideration infants' varying needs for immune protection across age or by sex. METHODOLOGY: A cross-sectional study analyzed archived milk specimens from breastfeeding mothers in Ariaal communities of northern Kenya surveyed during the 2006 Horn-of-Africa drought. Multiple regression models for ln-transformed sIgA were constructed using maternal nutrition, infant age/sex and their interactions as predictors. Maternal nutrition variables included iron-deficiency anemia (IDA), vitamin A deficiency (VAD) and mid-upper arm circumference (MUAC). Infant vulnerability was considered high in young age and/or male sex. RESULTS AND IMPLICATIONS: Milk sIgA did not significantly differ by maternal IDA. Milk sIgA increased with infant age and maternal MUAC ( LAY SUMMARY: Human milk sIgA antibody content was low for younger infants among vitamin A deficient mothers. Among mothers with small arm-circumference, milk sIgA was lower for sons. Double burden of raising young or male infants with high needs for immune protection and being malnourished, might lower maternal sIgA delivery to milk.
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