Evidence map›Paper›PMID 32405407›Full record

ArticleFood science & nutrition2020

Eggshell membrane powder lowers plasma triglyceride and liver total cholesterol by modulating gut microbiota and accelerating lipid metabolism in high-fat diet-fed mice.

Nurul Shazini Ramli, Huijuan Jia, Ayumu Sekine, Weida Lyu, Kyohei Furukawa, Kenji Saito, Yukio Hasebe, Hisanori Kato

Open access · hybridAbstract read
In one paragraph

Article in Food science & nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Nurul Shazini RamliGraduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan.
Huijuan JiaGraduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan.
Ayumu SekineGraduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan.
Weida LyuGraduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan.
Kyohei FurukawaGraduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan.
Kenji SaitoGraduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan.
Yukio HasebeALMADO Inc. Tokyo Japan.
Hisanori KatoGraduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan.ORCID https://orcid.org/0000-0001-9140-7698
The University of Tokyo · JPUniversiti Putra Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a major global lifestyle disorder associated with gut microbiota. The health benefits of eggshell membrane (ESM) have been shown in previous reports, particularly as regards gut microbiota composition. Here, we investigated whether ESM improves lipid metabolism and alters gut microbiota in high-fat diet-fed mice. A total of 20 C57BL/6J mice aged 6 weeks were given either a control diet (CON), high-fat diet (HFD), or high-fat diet + 8% ESM powder (HESM) for 20 weeks. ESM supplementation in HFD-fed mice reduced plasma triglycerides (TG) and liver total cholesterol (TC) and upregulated the expression of lipid metabolism genes carnitine palmitoyltransferase 1A and suppressor of cytokine signaling 2. Microbiota analysis showed increased relative abundance of the anti-obesity bacterium,

Indexed as

cholesteroleggshell membranegut microbiotahigh‐fat dietlipid metabolismtriglycerides

Identifiers

PMID32405407
PMCPMC7215208
OpenAlexW3014959038

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.