ArticleIranian journal of basic medical sciences2020
Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and
Article in Iranian journal of basic medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Shared immune-inflammatory gene networks and drug prediction in polycystic ovary syndrome and type 2 diabetes mellitus: a bioinformatics and experimental validation study.Frontiers in endocrinology · 2026Article
- Micronutrients in polycystic ovary syndrome: molecular pathways, deficiencies, and therapeutic potential.Frontiers in endocrinology · 2026Review
- Beneficial Effects of Curcumin in Polycystic Ovary Syndrome: A Review of Recent Literature and Underlying Mechanisms.Current medicinal chemistry · 2025Review
- Article
- Copper in Gynecological Diseases.International journal of molecular sciences · 2023Review
- Zinc Homeostasis: An Emerging Therapeutic Target for Neuroinflammation Related Diseases.Biomolecules · 2023Review
- Interplay of Gut Microbiota in Polycystic Ovarian Syndrome: Role of Gut Microbiota, Mechanistic Pathways and Potential Treatment Strategies.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Rhamnocitrin Attenuates Ovarian Fibrosis in Rats with Letrozole-Induced Experimental Polycystic Ovary Syndrome.Oxidative medicine and cellular longevity · 2022Article
- The Content of Minerals in the PCOS Group and the Correlation with the Parameters of Metabolism.Nutrients · 2021Article
- The Effects of Zinc Methionine on Reproductive and Thyroid Hormones in Rats with Polycystic Ovarian Syndrome.Advanced biomedical research · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesZinc is an effective factor in the reproductive system. Insulin resistance (IR) is known as an important disorder in patients with polycystic ovary syndrome (PCOS). Mammalian target of rapamycin ( MATERIALS AND
methodsExperimental treatments were performed on control and treated groups, consisting of healthy controls (Control, water, and standard feed intake and daily injection of sesame oil alone), Polycystic control (PCO, injection of 4 mg/kg estradiol valerate (EV) for four weeks). Treated groups (PCO-ZM 25, PCO-ZM 75, and PCO-ZM 175) after 4 weeks of receiving EV, were daily given three levels of 25, 75, and 175 mg zinc methionine/kg BW for 15 days, respectively.
resultsInjection of EV dramatically increased body and ovarian weights, levels of LH, testosterone, estradiol, triglyceride, fasting insulin, fasting glucose, HOMA-IR, IGF-1, gene expression of
conclusionOrganic zinc showed beneficial effects in the EV induced PCOS rats via decreased insulin resistance and
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