ArticleResearch in autism spectrum disorders2019
Age Group Differences in Executive Network Functional Connectivity and Relationships with Social Behavior in Men with Autism Spectrum Disorder.
Article in Research in autism spectrum disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic.Autism research : official journal of the International Society for Autism Research · 2025Pooled it
- Atypical antipsychotics for autism spectrum disorder: a network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Quality of life in adults with autism spectrum disorder: influence of age, sex, and a controlled, randomized mindfulness-based stress reduction pilot intervention.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Trial
- How Can Graph Theory Inform the Dual-stream Model of Speech Processing? A Resting-state Functional Magnetic Resonance Imaging Study of Stroke and Aphasia Symptomology.Journal of cognitive neuroscience · 2025Article
- Autism Spectrum Disorder in adults: an integrative review about strategies for promotion and maintenance of quality of life.Sao Paulo medical journal = Revista paulista de medicina · 2025Review
- Adapting the PEERSHealthcare (Basel, Switzerland) · 2024Article
- Central Executive and Default Mode Networks: An Appraisal of Executive Function and Social Skill Brain-Behavior Correlates in Youth with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2024Article
- Different functional connectivity optimal frequency in autism compared with healthy controls and the relationship with social communication deficits: Evidence from gene expression and behavior symptom analyses.Human brain mapping · 2023Article
- Sex-related brain connectivity correlates of compensation in adults with autism: insights into female protection.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Effects of age on the hippocampus and verbal memory in adults with autism spectrum disorder: Longitudinal versus cross-sectional findings.Autism research : official journal of the International Society for Autism Research · 2022Article
- Parallel age-related cognitive effects in autism: A cross-sectional replication study.Autism research : official journal of the International Society for Autism Research · 2022Article
- Electrophysiological signatures of brain aging in autism spectrum disorder.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Preliminary findings of accelerated visual memory decline and baseline brain correlates in middle-age and older adults with autism: The case for hippocampal free-water.Frontiers in aging neuroscience · 2022Article
- Brief Report: Using Cognitive Screeners in Autistic Adults.Journal of autism and developmental disorders · 2021Article
- The Lost Neural Hierarchy of the Autistic Self-Locked-Out of the Mental Self and Its Default-Mode Network.Brain sciences · 2021Review
- Ageing and heterogeneity regarding autism spectrum conditions: a protocol paper of an accelerated longitudinal study.BMJ open · 2021Article
- Editorial: Sex Differences in the Autistic Brain.Frontiers in integrative neuroscience · 2021Article
- Bilingualism, Executive Function, and the Brain: Implications for Autism.Neurobiology of language (Cambridge, Mass.) · 2021Review
- The social responsiveness scale is an efficient screening tool for autism spectrum disorder traits in adults with anorexia nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2020Article
- Executive Functioning in 60+ Autistic Males: The Discrepancy Between Experienced Challenges and Cognitive Performance.Journal of autism and developmental disorders · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundResearch suggests adults with autism spectrum disorder (ASD) may use executive functions to compensate for social difficulties. Given hallmark age-related declines in executive functioning and the executive brain network in normal aging, there is concern that older adults with ASD may experience further declines in social functioning as they age. In a male-only sample, we hypothesized: 1) older adults with ASD would demonstrate greater ASD-related social behavior than young adults with ASD, 2) adults with ASD would demonstrate a greater age group reduction in connectivity of the executive brain network than neurotypical (NT) adults, and 3) that behavioral and neural mechanisms of executive functioning would predict ASD-related social difficulties in adults with ASD.
methodsParticipants were a cross-sectional sample of non-intellectually disabled young (ages 18-25) and middle-aged (ages 40-70) adult men with ASD and NT development (young adult ASD:
resultsWe did not confirm a significant age group difference for adults with ASD on the SRS-2 Total Score; however, exploratory analysis revealed middle-age men with ASD had higher scores on the SRS-2 Social Cognition Subscale than young adult men with ASD. Exacerbated age group reductions in EN functional connectivity were confirmed (left dlPFC) in men with ASD compared to NT, such that older adults with ASD demonstrated the greatest levels of hypoconnectivity. A significant correlation was confirmed between dlPFC connectivity and the SRS-2 Total Score in middle-age men with ASD, but not young adult men with ASD. Furthermore, exploratory analysis revealed a significant correlation with the SRS-2 Social Cognition Subscale for young and middle-aged ASD groups and ToL Total Moves.
conclusionsOur findings suggest that ASD-related difficulties in social cognition and EN hypoconnectivity may get worse with age in men with ASD and is related to executive functioning. Further, exacerbated EN hypoconnectivity associated with older age in ASD may be a mechanism of increased ASD-related social cognition difficulties in older adults with ASD. Given the cross-sectional nature of this sample, longitudinal replication is needed.
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