Evidence map›Paper›PMID 32405276›Full record

ArticleProceedings. IEEE International Conference on Computer Vision

Conditional Recurrent Flow: Conditional Generation of Longitudinal Samples with Applications to Neuroimaging.

Seong Jae Hwang, Zirui Tao, Won Hwa Kim, Vikas Singh

Abstract read
In one paragraph

Article in Proceedings. IEEE International Conference on Computer Vision. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. A Variational Approximation for Analyzing the Dynamics of Panel Data.Uncertainty in artificial intelligence : proceedings of the ... conference. Conference on Uncertainty in Artificial Intelligence · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Seong Jae HwangUniv. of Pittsburgh.
Zirui TaoUniv. of Wisconsin-Madison.
Won Hwa KimUniv. of Texas at Arlington.
Vikas SinghUniv. of Wisconsin-Madison.

Funding

Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2019 to 2026
$34.5M
Research Training for Computation and Informatics in Biology and MedicineT15LM007359 · NLM · UNIVERSITY OF WISCONSIN-MADISON · PI Mark W. Craven, Colin Noel Dewey · 2002 to 2026
$22.6M
Wisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CHAPPELL, RICHARD J · 2009 to 2018
$16.2M
TrainingU54AI117924 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI CRAVEN, MARK W. · 2014 to 2018
$11.3M
White matter degeneration: biomarkers in preclinical Alzheimer's DiseaseR01AG037639 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA · 2012 to 2023
$5.3M
Algebraic Formulations for Characterizing Structural Brain Connectivity Changes and Pathology Transmission Networks in Preclinical Alzheimer's DiseaseRF1AG059312 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA, SINGH, VIKAS · 2019 to 2019
$1.8M
Maximizing Power in AD Clinical Trials via Multimodal Machine LearningR01AG040396 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SINGH, VIKAS · 2012 to 2015
$1.1M
Manifold-valued statistical models for longitudinal morphometic analysis in preclinical Alzheimer's disease (AD)R01EB022883 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, STERLING C, SINGH, VIKAS · 2016 to 2018
$995k
CRCNS: Pooling Multisite data and Staistical Tests for analyzing biomarkers of Alzheimer's diseaseRF1AG062336 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SINGH, VIKAS · 2018 to 2018
$660k
NIAID NIH HHS U54 AI117924NIA NIH HHS P30 AG062715NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG037639NIA NIH HHS R01 AG040396NIA NIH HHS RF1 AG059312NIA NIH HHS RF1 AG062336NIBIB NIH HHS R01 EB022883NLM NIH HHS T15 LM007359
6 · The paper itself

Abstract

We develop a conditional generative model for longitudinal image datasets based on sequential invertible neural networks. Longitudinal image acquisitions are common in various scientific and biomedical studies where often each image sequence sample may also come together with various secondary (fixed or temporally dependent) measurements. The key goal is not only to estimate the parameters of a deep generative model for the given longitudinal data, but also to enable evaluation of how the temporal course of the generated longitudinal samples are influenced as a function of induced changes in the (secondary) temporal measurements (or events). Our proposed formulation incorporates recurrent subnetworks and temporal context gating, which provide a smooth transition in a temporal sequence of generated data that can be easily informed or modulated by secondary temporal conditioning variables. We show that the formulation works well despite the smaller sample sizes common in these applications. Our model is validated on two video datasets and a longitudinal Alzheimer's disease (AD) dataset for both quantitative and qualitative evaluations of the generated samples. Further, using our generated longitudinal image samples, we show that we can capture the pathological progressions in the brain that turn out to be consistent with the existing literature, and could facilitate various types of downstream statistical analysis.

Identifiers

PMID32405276
PMCPMC7220239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.