ArticleScientific reports2020
Anatomically revealed morphological patterns of pyramidal neurons in layer 5 of the motor cortex.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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18 citing papers in PubMed, 30 citations in OpenAlex.
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- Plastic Arbor: A modern simulation framework for synaptic plasticity-From single synapses to networks of morphological neurons.PLoS computational biology · 2026Article
- Scalable spatial single-cell transcriptomics and translatomics in 3D thick tissue blocks.Nature methods · 2025Article
- Generating brain-wide connectome using synthetic axonal morphologies.Nature communications · 2025Article
- Unique nicotinic responses are present in distinct subtypes of mouse medial prefrontal layer V pyramidal neurons.Scientific reports · 2025Article
- Connectivity of single neurons classifies cell subtypes in mouse brains.Nature methods · 2025Article
- Molecular investigation of ergot alkaloid ergotamine's modulatory effects on glycine receptors expressed inComputational and structural biotechnology journal · 2025Article
- Learning and Control in Motor Cortex across Cell Types and Scales.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
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- From Individual to Population: Circuit Organization of Pyramidal Tract and Intratelencephalic Neurons in Mouse Sensorimotor Cortex.Research (Washington, D.C.) · 2024Article
- Neuronal Connectivity as a Determinant of Cell Types and Subtypes.Research square · 2023Article
- Different subtypes of motor cortex pyramidal tract neurons projects to red and pontine nuclei.Frontiers in cellular neuroscience · 2022Article
- Cellular anatomy of the mouse primary motor cortex.Nature · 2021Article
- Untangling the cortico-thalamo-cortical loop: cellular pieces of a knotty circuit puzzle.Nature reviews. Neuroscience · 2021Review
- Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency.Neurobiology of disease · 2021Article
- Skeleton optimization of neuronal morphology based on three-dimensional shape restrictions.BMC bioinformatics · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal cell types are essential to the comprehensive understanding of the neuronal function and neuron can be categorized by their anatomical property. However, complete morphology data for neurons with a whole brain projection, for example the pyramidal neurons in the cortex, are sparse because it is difficult to trace the neuronal fibers across the whole brain and acquire the neuron morphology at the single axon resolution. Thus the cell types of pyramidal neurons have yet to be studied at the single axon resolution thoroughly. In this work, we acquire images for a Thy1 H-line mouse brain using a fluorescence micro-optical sectioning tomography system. Then we sample 42 pyramidal neurons whose somata are in the layer 5 of the motor cortex and reconstruct their morphology across the whole brain. Based on the reconstructed neuronal anatomy, we analyze the axonal and dendritic fibers of the neurons in addition to the soma spatial distributions, and identify two axonal projection pattern of pyramidal tract neurons and two dendritic spreading patterns of intratelencephalic neurons. The raw image data are available upon request as an additional asset to the community. The morphological patterns identified in this work can be a typical representation of neuron subtypes and reveal the possible input-output function of a single pyramidal neuron.
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